Synthesis and Biological Studies of Novel Aminophosphonates and Their Metal Carbonyl Complexes (Fe, Ru).

The quest to find new inhibitors of biologically relevant targets is considered an important strategy to introduce new drug candidates for the treatment of neurodegenerative diseases. A series of (aminomethyl)benzylphosphonates - and their metallocarbonyl iron - and ruthenium - complexes were designed, synthesized, and evaluated for their inhibitory potentials against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) by determination of IC. Metallocarbonyl derivatives, in general, did not show significant inhibition activity against these enzymes, the most potent inhibitor was the (aminomethyl)benzylphosphonate (IC = 1.215 µM against AChE). Molecular docking analysis of AChE and (aminomethyl)benzylphosphonates - showed the strongest interactions of and AChE compared to isomers and . Cytotoxicity studies of synthesized compounds towards the V79 cell line were also performed and discussed.