Department of Physiology, Albert Szent-Györgyi Medical School, University of Szeged, H-6720 Szeged, Hungary.
Department of Medical Imaging, Division of Nuclear Medicine and Translational Imaging, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Int J Mol Sci. 2022 Jul 25;23(15):8186. doi: 10.3390/ijms23158186.
Recently, morphological impairments have been detected in the brain of a triple-hit rat schizophrenia model (Wisket), and delayed depressive effects of caffeine treatment in both control and Wisket animals have also been shown. The aims of this study were to determine the basal and caffeine-induced acute (30 min) and delayed (24 h) changes in the cerebral fluorodeoxyglucose (F-FDG) uptake by positron emission tomography (PET) in control and Wisket rats. No significant differences were identified in the basal whole-brain metabolism between the two groups, and the metabolism was not modified acutely by a single intraperitoneal caffeine (20 mg/kg) injection in either group. However, one day after caffeine administration, significantly enhanced F-FDG uptake was detected in the whole brain and the investigated areas (hippocampus, striatum, thalamus, and hypothalamus) in the control group. Although the Wisket animals showed only moderate enhancements in the F-FDG uptake, significantly lower brain metabolism was observed in this group than in the caffeine-treated control group. This study highlights that the basal brain metabolism of Wisket animals was similar to control rats, and that was not influenced acutely by single caffeine treatment at the whole-brain level. Nevertheless, the distinct delayed responsiveness to this psychostimulant in Wisket model rats suggests impaired control of the cerebral metabolism.
最近，在三重打击精神分裂症大鼠模型（Wisket）的大脑中发现了形态损伤，并且还显示出咖啡因治疗对对照和 Wisket 动物的延迟抑郁作用。本研究的目的是确定通过正电子发射断层扫描（PET）在对照和 Wisket 大鼠中观察到的基础和咖啡因诱导的急性（30 分钟）和延迟（24 小时）大脑氟脱氧葡萄糖（F-FDG）摄取的变化。两组之间的基础全脑代谢没有明显差异，并且在两组中单次腹腔内咖啡因（20 mg/kg）注射均未急性改变代谢。然而，在咖啡因给药后一天，在对照组的整个大脑和研究区域（海马体、纹状体、丘脑和下丘脑）中检测到 F-FDG 摄取明显增强。尽管 Wisket 动物的 F-FDG 摄取仅适度增强，但与咖啡因治疗的对照组相比，该组的大脑代谢明显降低。这项研究强调，Wisket 动物的基础大脑代谢与对照大鼠相似，并且在整个大脑水平上，单次咖啡因治疗不会急性影响。然而，Wisket 模型大鼠对这种精神兴奋剂的明显延迟反应表明大脑代谢的控制受损。
