Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Budapest, Hungary; János Szentágothai Doctoral School, Semmelweis University, Budapest, Hungary.
Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Budapest, Hungary; János Szentágothai Doctoral School, Semmelweis University, Budapest, Hungary.
Curr Opin Pharmacol. 2021 Dec;61:106-113. doi: 10.1016/j.coph.2021.09.003. Epub 2021 Oct 21.
Schizophrenia is a common psychiatric disorder which affects approximately 1% of the population worldwide. However, the complexity of etiology, treatment resistance and side effects induced by current antipsychotics, relapse prevention, and psychosocial rehabilitation are still to be uncovered. Caffeine, as the world's most widely consumed psychoactive drug, plays a crucial role in daily life. Plenty of preclinical and clinical evidence has illustrated that caffeine consumption could have a beneficial effect on schizophrenia. In this review, we firstly summarize the factors associated with the caffeine-induced beneficial effect. Then, a variety of mechanism of actions independent of adenosine receptor signaling will be discussed with an emphasis on the potential contribution of the microbiome-gut-brain axis to provide more possibilities for future therapeutic, prognosis, and social rehabilitation strategy.
精神分裂症是一种常见的精神疾病，影响着全球约 1%的人口。然而，目前抗精神病药物的病因复杂性、治疗抵抗性和副作用、复发预防以及社会心理康复等问题仍有待揭示。咖啡因作为世界上使用最广泛的精神活性药物，在日常生活中起着至关重要的作用。大量的临床前和临床证据表明，咖啡因的摄入可能对精神分裂症有有益的影响。在这篇综述中，我们首先总结了与咖啡因诱导的有益作用相关的因素。然后，我们将讨论多种不依赖于腺苷受体信号的作用机制，并重点讨论微生物组-肠道-大脑轴的潜在贡献，为未来的治疗、预后和社会康复策略提供更多的可能性。
