State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China.
Cancer Center, Medical Research Institute, Southwest University, Chongqing 400716, China.
Int J Mol Sci. 2022 Jul 26;23(15):8231. doi: 10.3390/ijms23158231.
B-cell-specific Moloney murine leukemia virus integration region 1 (Bmi-1, also known as RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved in regulating cell proliferation, differentiation and senescence, and maintaining the self-renewal of stem cells. Many studies in recent years have emphasized the role of Bmi-1 in the occurrence and development of tumors. In fact, Bmi-1 has multiple functions in cancer biology and is closely related to many classical molecules, including Akt, c-MYC, Pten, etc. This review summarizes the regulatory mechanisms of Bmi-1 in multiple pathways, and the interaction of Bmi-1 with noncoding RNAs. In particular, we focus on the pathological processes of Bmi-1 in cancer, and explore the clinical relevance of Bmi-1 in cancer biomarkers and prognosis, as well as its implications for chemoresistance and radioresistance. In conclusion, we summarize the role of Bmi-1 in tumor progression, reveal the pathophysiological process and molecular mechanism of Bmi-1 in tumors, and provide useful information for tumor diagnosis, treatment, and prognosis.
B 细胞特异性 Moloney 鼠白血病病毒整合区 1（Bmi-1，也称为 RNF51 或 PCGF4）是 PcG 基因家族的重要成员之一，参与调节细胞增殖、分化和衰老，维持干细胞的自我更新。近年来的许多研究强调了 Bmi-1 在肿瘤发生和发展中的作用。事实上，Bmi-1 在癌症生物学中有多种功能，与 Akt、c-MYC、Pten 等许多经典分子密切相关。本综述总结了 Bmi-1 在多条通路中的调节机制，以及 Bmi-1 与非编码 RNA 的相互作用。特别是，我们重点关注 Bmi-1 在癌症中的病理过程，探讨 Bmi-1 在癌症生物标志物和预后中的临床相关性，以及其对化疗耐药性和放疗耐药性的影响。总之，我们总结了 Bmi-1 在肿瘤进展中的作用，揭示了 Bmi-1 在肿瘤中的病理生理过程和分子机制，为肿瘤的诊断、治疗和预后提供了有用的信息。
