球蛋白与 2 型糖尿病患者糖尿病肾病的相关性：一项横断面研究。
Association Between Globulin and Diabetic Nephropathy in Type2 Diabetes Mellitus Patients: A Cross-Sectional Study.
机构信息
Renal Department, Dezhou People's Hospital, Dezhou, China.
出版信息
Front Endocrinol (Lausanne). 2022 Jul 8;13:890273. doi: 10.3389/fendo.2022.890273. eCollection 2022.
BACKGROUND
With the development of economy, the living standard of people all over the world has been greatly improved, and the incidence of diabetes is also increasing. Many people with diabetes also develop other complications that reduce their quality of life. Diabetic nephropathy is a common complication of type2 diabetes. Understanding the related factors of diabetic nephropathy is greatly significant to control the occurrence of diabetic nephropathy and improve patient's life quality.
DATA AND METHODS
Data were collected from 2009 to 2018 in NHANES. Curve fitting graph was performed to investigate the association between globulin (GLB) and diabetic nephropathy(DN). Four logistic regression models were conducted to control the potential confounding factors. Subgroup analysis was carried out to assess the stability of results.
RESULTS
GLB was positively correlated with the occurrence of DN after controlling for potential confounders. Higher GLB was associated with an increased risk of diabetic nephropathy [odds ratio(OR), 1.10; 95% confidence interval (CI), 1.07-1.13, < 0.001].
CONCLUSIONS
In this cross-sectional study, GLB was significant positively correlated with the occurrence of DN in patients with type2 diabetes mellitus.
背景
随着经济的发展，全世界人民的生活水平得到了极大的提高，糖尿病的发病率也在不断上升。许多糖尿病患者还会出现其他并发症，降低他们的生活质量。糖尿病肾病是 2 型糖尿病的常见并发症。了解糖尿病肾病的相关因素对于控制糖尿病肾病的发生和提高患者的生活质量具有重要意义。
数据和方法
数据来自 2009 年至 2018 年的 NHANES。通过曲线拟合图研究球蛋白(GLB)与糖尿病肾病(DN)之间的关系。进行了四个逻辑回归模型来控制潜在的混杂因素。进行了亚组分析以评估结果的稳定性。
结果
在控制了潜在混杂因素后，GLB 与 DN 的发生呈正相关。较高的 GLB 与糖尿病肾病的风险增加相关[比值比(OR)，1.10；95%置信区间(CI)，1.07-1.13， < 0.001]。
结论
在这项横断面研究中，GLB 与 2 型糖尿病患者 DN 的发生显著正相关。
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