Sagoo Manpreet K, Gnudi Luigi
Faculty of Life Sciences & Medicine, School of Cardiovascular Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London, UK.
Methods Mol Biol. 2020;2067:3-7. doi: 10.1007/978-1-4939-9841-8_1.
Diabetic nephropathy (DN) is one of the most feared diabetic chronic microvascular complications and the major cause of end-stage renal disease (ESRD). The classical presentation of DN is characterized by hyperfiltration and albuminuria in the early phases which is then followed by a progressive renal function decline. The presentation of diabetic kidney disease (DKD) can vary especially in patients with T2DM where concomitant presence of other glomerular/tubular pathologies and severe peripheral vascular disease can become important confounders. All-cause mortality in individuals with DKD is approximately 30 times higher than that in diabetic patients without nephropathy and a great majority of patients with DKD will die from cardiovascular disease before they reach ESRD. The management of metabolic and hemodynamic perturbations for the prevention and for the delay of progression of DKD is very important. DKD is a global challenge and a significant social and economic burden; research should aim at developing new ideas to tackle this devastating condition.
糖尿病肾病（DN）是最令人担忧的糖尿病慢性微血管并发症之一，也是终末期肾病（ESRD）的主要原因。DN的典型表现是早期出现高滤过和蛋白尿，随后肾功能进行性下降。糖尿病肾病（DKD）的表现可能各不相同，尤其是在2型糖尿病患者中，其他肾小球/肾小管病变和严重外周血管疾病的并存可能成为重要的混杂因素。DKD患者的全因死亡率比无肾病的糖尿病患者高出约30倍，绝大多数DKD患者在达到ESRD之前会死于心血管疾病。管理代谢和血流动力学紊乱以预防和延缓DKD的进展非常重要。DKD是一项全球挑战，也是一项重大的社会和经济负担；研究应旨在开发新思路来应对这种毁灭性疾病。
