Gui Huiming, Wang Hanzhang, Kaushik Dharam, Rodriguez Ronald, Wang Zhiping
Department of Urology, Institute of Urology, Gansu Nephro-Urological Clinical Center, Key Laboratory of Urological Diseases in Gansu Province, Lanzhou University Second Hospital, Lanzhou, China.
Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX United States.
Front Surg. 2022 Jul 11;9:773270. doi: 10.3389/fsurg.2022.773270. eCollection 2022.
To compare the outcomes and postoperative quality of life of patients with renal calculi who underwent standard percutaneous nephrolithotomy (sPNL), mini-invasive percutaneous nephrolithotomy (mPNL) or mPNL with an endoscopic surgical monitoring system (ESMS) using a retrospective clinical trial.
Eighty-six adult patients with renal stones who were treated with sPNL were retrospectively compared to ninety-two patients who were treated with mPNL between July 2014 and December 2017. Next, further studies were retrospectively conducted using a matched paired method. The ninety-two patients treated with mPNL were divided into two groups based on whether the endoscopic surgical monitoring system (ESMS) was used (ESMS-mPNL vs. non-ESMS-mPNL). The ESMS used strain gauge transducers to measure the inflow and outflow of irrigation solution. Bleeding and fluid absorption during endoscopic surgery could be accurately calculated by computer program in ESMS.
The fluoroscopy time, complication rate, stone-free status and clinically insignificant residual fragment (CIRF) rate were not significantly different between the two groups (sPNL vs. mPNL). The mPNL group had a significantly longer operation time than the sPNL group, and the mPNL group exhibited a markedly reduced 12-h postoperative visual analogue pain scale (VAS) score, mean hospitalization time, and return to work time, had slightly reduced haemoglobin loss, and underwent more tubeless operations. Moreover, among the 92 patients who underwent mPNL, the operation time (= 0.090), complication rate (= 0.996), stone-free status (= 0.731), CIRF rates (= 0.125) and number of tubeless operations (= 0.760) were not significantly different between the two subgroups (non-ESMS-mPNL vs. ESMS-mPNL); however, the patients in the ESMS-mPNL group had significantly longer operation times than those in the non-ESMS-mPNL subgroup, along with marked reductions in irrigation fluid absorption, blood loss, haemoglobin loss, 12 h postoperative VAS score, mean hospitalization time, and return to work time.
mPNL is less painful than sPNL in patients undergoing treatment for 20-40 mm renal stones. Similar stone-free rates were achieved by the two procedures, but mPNL was superior to sPNL in terms of blood loss, discomfort, hospitalization time and return to work time. We think that ESMS-mPNL is less painful for patients and more efficacious than non-ESMS-mPNL, and ESMS-mPNL achieves a stone-free rate that is similar to non-ESMS-mPNL in patients receiving treatment for 20-40 mm kidney stones.
采用回顾性临床试验比较接受标准经皮肾镜取石术(sPNL)、微创经皮肾镜取石术(mPNL)或带内镜手术监测系统(ESMS)的mPNL治疗的肾结石患者的治疗结果和术后生活质量。
回顾性比较2014年7月至2017年12月期间接受sPNL治疗的86例成年肾结石患者和接受mPNL治疗的92例患者。接下来,采用配对法进行进一步回顾性研究。将92例接受mPNL治疗的患者根据是否使用内镜手术监测系统(ESMS)分为两组(ESMS-mPNL组与非ESMS-mPNL组)。ESMS使用应变片式传感器测量冲洗液的流入和流出。ESMS可通过计算机程序准确计算内镜手术期间的出血量和液体吸收量。
两组(sPNL组与mPNL组)的透视时间、并发症发生率、结石清除状态和临床无意义残留碎片(CIRF)率无显著差异。mPNL组的手术时间明显长于sPNL组,且mPNL组术后12小时视觉模拟疼痛量表(VAS)评分、平均住院时间和恢复工作时间显著缩短,血红蛋白损失略有减少,无管手术更多。此外,在92例接受mPNL治疗的患者中,两个亚组(非ESMS-mPNL组与ESMS-mPNL组)之间的手术时间(=0.090)、并发症发生率(=0.996)、结石清除状态(=0.731)、CIRF率(=0.125)和无管手术数量(=0.760)无显著差异;然而,ESMS-mPNL组患者的手术时间明显长于非ESMS-mPNL亚组,同时冲洗液吸收、失血量、血红蛋白损失、术后12小时VAS评分、平均住院时间和恢复工作时间显著减少。
对于接受20 - 40 mm肾结石治疗的患者,mPNL比sPNL疼痛轻。两种手术的结石清除率相似,但mPNL在失血量、不适程度、住院时间和恢复工作时间方面优于sPNL。我们认为,ESMS-mPNL对患者的疼痛较轻,比非ESMS-mPNL更有效,并且在接受20 - 40 mm肾结石治疗的患者中,ESMS-mPNL的结石清除率与非ESMS-mPNL相似。