Rahman Md Ashrafur, Shanjana Yeasna, Ahmed Md Shakil, Dhama Kuldeep, Hasan Fahim Mahadi, Mahmud Tarif, Shuvo Arif Anzum, Milan Zahid Hossain, Rahman Mohammad Saydur, Roy Arpita, Bhuiyan Mohiuddin Ahmed, Islam Md Rabiul
Department of Pharmaceutical Sciences, North South University, Bashundhara, Dhaka, Bangladesh.
Department of Environmental Sciences, North South University, Bashundhara, Dhaka, Bangladesh.
Clin Pathol. 2022 Jul 23;15:2632010X221114807. doi: 10.1177/2632010X221114807. eCollection 2022 Jan-Dec.
Abnormalities in hematology and comorbidities might have a role in chronic kidney disease (CKD) patients. However, the exact relationships between hematological parameters and the severity of CKD are not well understood. Also, the underlying mechanisms remain under investigation. The present study aimed to evaluate the association of different blood parameters and comorbidities among hospitalized CKD patients in Bangladesh.
The present study enrolled admitted CKD patients at Evercare Hospital Ltd, Dhaka, Bangladesh, from January 1, 2021, to August 1, 2021. For this study, the demographic and clinical information of the patients were collected. Then some routine blood tests for the hematological profile of CKD patients were performed. Finally, several statistical methods were performed and data interpretations were done to evaluate the role of hematological changes on CKD patients.
Among 300 patients, early-stage CKD patients (ESCKDP) and advanced-stage CKD patients (ASCKDP) were 153 and 147, respectively. The decreased levels of hemoglobin (Hb) and red blood cell (RBC) in ASCKDP were observed. However, the present study found increased levels of corpuscular Hb in ASCKDP than ESCKDP. Also, the present study noticed correlations between these changes and the severity of CKD. Also, we observed a significant difference in age and body mass index between ESCKDP and ASCKDP.
Based on our results, lower Hb and RBC levels may use in assessing the severity and the treatment decisions of CKD patients in the hospital setting. Therefore, our findings may assist with developing a treatment protocol for hospitalized CKD patients.
血液学异常和合并症可能在慢性肾脏病（CKD）患者中起作用。然而，血液学参数与CKD严重程度之间的确切关系尚未完全明确。此外，潜在机制仍在研究中。本研究旨在评估孟加拉国住院CKD患者不同血液参数与合并症之间的关联。
本研究纳入了2021年1月1日至2021年8月1日期间在孟加拉国达卡的Evercare医院有限公司收治的CKD患者。对于本研究，收集了患者的人口统计学和临床信息。然后对CKD患者进行了一些常规血液检查以了解血液学特征。最后，采用了几种统计方法并进行数据解读，以评估血液学变化对CKD患者的作用。
在300例患者中，早期CKD患者（ESCKDP）和晚期CKD患者（ASCKDP）分别为153例和147例。观察到ASCKDP患者的血红蛋白（Hb）和红细胞（RBC）水平降低。然而，本研究发现ASCKDP患者的平均红细胞血红蛋白含量高于ESCKDP患者。此外，本研究注意到这些变化与CKD严重程度之间的相关性。而且，我们观察到ESCKDP和ASCKDP患者在年龄和体重指数方面存在显著差异。
根据我们的结果，较低的Hb和RBC水平可用于评估医院环境中CKD患者的严重程度和治疗决策。因此，我们的研究结果可能有助于制定住院CKD患者的治疗方案。
