Miyawaki S, Kohmoto K, Kurata N, Ofuji T
Arthritis Rheum. 1978 Sep-Oct;21(7):803-10. doi: 10.1002/art.1780210711.
Two antigens, temporarily referred to as MU and TM antigens after the original serum, that are closely related to the nucleolus have been identified in the nuclear soluble extract. Both antigens reacted with the sera of a small number of patients with various connective tissue diseases, and both were different from antigens described previously in these disorders. MU antigen was sensitive to the digestion with RNase and trypsin, and was shown to be equivalent to the nuclear ribosomal components in the nuclear extract. TM antigen was resistant to the digestion with RNase and trypsin, and was localized in the nucleolus and extranucleolar portion of nuclei, but the precise nature of TM has not been established.
在核可溶性提取物中已鉴定出两种抗原，根据原始血清暂时称为MU和TM抗原，它们与核仁密切相关。这两种抗原均与少数患有各种结缔组织疾病的患者血清发生反应，且两者均与先前在这些疾病中描述的抗原不同。MU抗原对核糖核酸酶（RNase）和胰蛋白酶消化敏感，并且已证明等同于核提取物中的核糖核蛋白成分。TM抗原对核糖核酸酶和胰蛋白酶消化具有抗性，定位于核仁及核仁外部分，但TM的确切性质尚未确定。
