Leibfarth J H, Persellin R H
Arthritis Rheum. 1976 Sep-Oct;19(5):851-6. doi: 10.1002/art.1780190503.
A distinguishing feature of the mixed connective tissue disease (MCTD) syndrome is the presence in the serum of antibody in high titer to ribonucleoprotein (RNP). To determine whether this was an exclusive observation, a large rheumatic disease population was surveyed for the presence of antibody in high titer to extractable nuclear antigens (ENA) including RNP. Of 650 sera examined, 440 (from 240 patients) had antinuclear antibody. Only 39 patients had serum antibody to ENA in titers greater than or equal to 1:200 dilution. In 16 the anti-ENA was shown by RNAse digestion to be anti-RNP. Although many clinical and laboratory characteristics were similar in these two groups, the patients more closely resembled the previously described MCTD syndrome and, importantly, less often had severe renal and central nervous system disease manifestations. Thus the presence of serum antibodies to ENA that are predominantly RNAse-sensitive (anti-RNP) helps to identify a rheumatic disease syndrome and also appears to have prognostic value.
混合性结缔组织病（MCTD）综合征的一个显著特征是血清中存在高滴度的抗核糖核蛋白（RNP）抗体。为了确定这是否是一项独特的观察结果，对一大群风湿性疾病患者进行了调查，以检测其血清中是否存在高滴度的针对包括RNP在内的可提取核抗原（ENA）的抗体。在检测的650份血清中，440份（来自240名患者）含有抗核抗体。只有39名患者的血清抗ENA抗体滴度大于或等于1:200稀释度。在16名患者中，经核糖核酸酶消化显示抗ENA抗体为抗RNP抗体。尽管这两组患者的许多临床和实验室特征相似，但这些患者与先前描述的MCTD综合征更为相似，重要的是，他们出现严重肾脏和中枢神经系统疾病表现的频率较低。因此，血清中主要对核糖核酸酶敏感的抗ENA抗体（抗RNP）的存在有助于识别一种风湿性疾病综合征，并且似乎还具有预后价值。
