Liaoning Province Key Laboratory of Forensic Bio-evidence Science, School of Forensic Medicine, China Medical University, Shenyang 110122, China.
The Third Clinical Department, China Medical University, Shenyang 110122, China.
Fa Yi Xue Za Zhi. 2022 Apr 25;38(2):258-262. doi: 10.12116/j.issn.1004-5619.2020.400911.
Exosomal microRNAs (miRNAs) are miRNAs that are mediated by exosomes to achieve cell-to-cell communication, and they are widespread in organisms. In recent years, the key role of the multiple biological functions of exosomal miRNAs in the occurrence and development of cardiovascular diseases has been confirmed by a large number of studies, which has become a hot spot in clinical and basic research. Sudden cardiac death caused by cardiovascular disease is one of the important contents in forensic medical identification. This article introduces the research progress of cardiovascular disease prediction, treatment and prognosis on exosomal miRNA. The prospects of the application in forensic medical identification are discussed.
外泌体 microRNAs（miRNAs）是通过外泌体介导实现细胞间通讯的 miRNAs，广泛存在于生物体中。近年来，大量研究证实了外泌体 miRNAs 在心血管疾病发生发展中的多种生物学功能的关键作用，成为临床和基础研究的热点。心血管疾病导致的心脏性猝死是法医鉴定中的重要内容之一。本文介绍了外泌体 miRNA 在心血管疾病预测、治疗和预后方面的研究进展，探讨了其在法医鉴定中的应用前景。
