Sha Xiao-Qi, Ge Xing-Yu, Jin Yi, Chen Tian, Ji Juan, Gu Zhi-Feng
Department of Stomatology, Affiliated Hospital of Nantong University, Nantong 226000, China.
Sheng Li Xue Bao. 2021 Dec 25;73(6):1035-1042.
Exosomes are nanometer-sized membranous extracellular vesicles that can be secreted by almost all types of cells in the body. Exosomes are involved in cell-to-cell communication through autocrine and paracrine forms. Exosomal microRNAs (miRNAs) are stable in plasma, urine and other body fluids, and have various biological functions. They play an irreplaceable role in the occurrence, development, immune regulation of systemic lupus erythematosus (SLE). Recent studies have proposed that exosomal miRNAs have promising application prospects in the pathogenesis, early diagnosis, and treatment of SLE. Therefore, this review aims to introduce the current research progress on exosomal miRNAs in SLE and analyze their potential application value.
外泌体是纳米级的膜性细胞外囊泡，几乎可由体内所有类型的细胞分泌。外泌体通过自分泌和旁分泌形式参与细胞间通讯。外泌体微小RNA（miRNA）在血浆、尿液和其他体液中稳定存在，并具有多种生物学功能。它们在系统性红斑狼疮（SLE）的发生、发展、免疫调节中发挥着不可替代的作用。最近的研究表明，外泌体miRNA在SLE的发病机制、早期诊断和治疗方面具有广阔的应用前景。因此，本综述旨在介绍目前关于SLE中外泌体miRNA的研究进展，并分析其潜在的应用价值。
