Department of Ophthalmology, Istanbul Haydarpasa Numune Training and Research Hospital, Uskudar, Turkey.
Department of Neurology, Fethiye State Hospital, Fethiye, Turkey.
Hosp Pract (1995). 2022 Oct;50(4):282-288. doi: 10.1080/21548331.2022.2107794. Epub 2022 Aug 2.
To compare posterior pole analysis and ganglion cell layer (GCL) of patients with Alzheimer's disease (AD) and controls.
Patients diagnosed with mild and moderate AD included in the study. Posterior pole analysis and GCL measurements were investigated by dividing the macula into superior and inferior hemifields and 5 corresponding zones.
There were no significant differences between groups for retinal thickness measurements in any retinal zone. GCL measurements showed lower measurements in moderate AD group for GCL thickness in the superior zone 2 (p:0.025) and inferior zone 2 (p = 0.048) compared to mild AD and controls. A moderate AD status was found to cause a decrease of 5.349 µm in the GCL-SZ2 value [p:0.037].
GCL measurements in the moderate AD group show significant thinning in superior and inferior Zone 2, which may be a biomarker for AD.
比较阿尔茨海默病（AD）患者和对照组的后极分析和神经节细胞层（GCL）。
本研究纳入了被诊断为轻度和中度 AD 的患者。通过将黄斑分为上半和下半视野以及 5 个相应区域，对后极分析和 GCL 测量进行了研究。
在任何视网膜区域，各组的视网膜厚度测量值均无显著差异。GCL 测量值显示，与轻度 AD 和对照组相比，中度 AD 组上区 2（p：0.025）和下区 2（p=0.048）的 GCL 厚度较低。中度 AD 状态导致 GCL-SZ2 值下降 5.349µm（p：0.037）。
中度 AD 组的 GCL 测量值在上下区 2 显示出明显变薄，这可能是 AD 的生物标志物。
