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中性粒细胞-淋巴细胞比值作为预测重度溃疡性结肠炎患者激素反应的指标:一项回顾性队列研究。

The neutrophil-lymphocyte ratio as a predictor of steroid response in patients with severe ulcerative colitis: a retrospective cohort study.

机构信息

Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico.

Colorectal Surgery, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán".

出版信息

Rev Esp Enferm Dig. 2023 Apr;115(4):197-199. doi: 10.17235/reed.2022.9006/2022.

DOI:10.17235/reed.2022.9006/2022
PMID:35899688
Abstract

In this study we assessed the neutrophil-lymphocyte ratio (NLR) as a predictor of steroid non-response (SNR) in patients with acute severe ulcerative colitis and found a NLR on day 3 (NLR-3) >6.1 as a suitable cutoff point to identify SNR (OR 3.44, 95%CI 1.22-9.66) with sensitivity, specificity, positive predictive value, negative predictive value, and AUROC of 66.75, 63.2%, 35.9%, 86%, and 0.650, respectively. A model including bowel movements, albumin levels, and a NLR-3>6.1 had an AUC of 0.812 to predict SNR, with acceptable calibration.

摘要

在这项研究中,我们评估了中性粒细胞-淋巴细胞比值(NLR)作为急性重度溃疡性结肠炎患者对类固醇无反应(SNR)的预测因子,发现第 3 天的 NLR(NLR-3)>6.1 是识别 SNR 的合适截断点(OR 3.44,95%CI 1.22-9.66),其敏感性、特异性、阳性预测值、阴性预测值和 AUC 分别为 66.75%、63.2%、35.9%、86%和 0.650。包括粪便次数、白蛋白水平和 NLR-3>6.1 的模型预测 SNR 的 AUC 为 0.812,校准良好。

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