State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
J Asian Nat Prod Res. 2022 Oct;24(10):925-934. doi: 10.1080/10286020.2022.2099385. Epub 2022 Jul 28.
Four new germacrane-type sesquiterpenoids (-) and two new guaiane-type sesquiterpenoids (-) were isolated from the fruits of Moretti. The structures of the new compounds were elucidated on the basis of spectroscopic analysis and X-ray diffraction experiment. Compounds , and showed the anti-inflammatory effects against the activation of NF-κB induced by lipopolysaccharide (LPS) with IC values of 20.12, 22.89 and 68.66 µM, respectively.
从 Moretti 的果实中分离得到了四个新的倍半萜 (-) 和两个新的愈创木烷型倍半萜 (-)。基于光谱分析和 X 射线衍射实验，确定了新化合物的结构。化合物 、 和 对脂多糖 (LPS) 诱导的 NF-κB 激活具有抗炎作用，IC 值分别为 20.12、22.89 和 68.66µM。
