苍耳果实中的新型苯丙素衍生物及其抗炎活性。
New phenylpropanoid derivatives from the fruits of Xanthium sibiricum and their anti-inflammatory activity.
作者信息
Jiang Hai, Yang Liu, Ma Guo-Xu, Xing Xu-Dong, Yan Mei-Ling, Zhang Yan-Yan, Wang Qiu-Hong, Yang Bing-You, Kuang Hai-Xue, Xu Xu-Dong
机构信息
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, PR China; Key Laboratory of Chinese MateriaMedica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, PR China.
Key Laboratory of Chinese MateriaMedica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, PR China.
出版信息
Fitoterapia. 2017 Mar;117:11-15. doi: 10.1016/j.fitote.2016.12.007. Epub 2016 Dec 23.
The fruits of Xanthium sibiricum Patr yielded five phenylpropanoid derivatives, named as xanthiumnolics A-E (1-5). Their structures were elucidated by spectroscopic analysis and comparison with literature data. The isolated ones were tested for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7, and compound 5 showed strong inhibitory activities with IC value of 8.73μM.
苍耳果实中分离得到5个苯丙素类衍生物，命名为苍耳酚A-E（1-5）。通过光谱分析并与文献数据对比确定了它们的结构。对分离得到的化合物进行了抗炎症活性测试，考察其对脂多糖（LPS）诱导的RAW 264.7细胞一氧化氮（NO）生成的影响，化合物5表现出较强的抑制活性，IC50值为8.73μM。
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