Zhan Jia-Lin, Huang Yan-Ling, Liang Qiao-Wen, Qu Xiao-Sheng, Dong Zi-Mei, Du Yi, Luo Wen-Jing
Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi Zhuang Autonomous Region, China.
Neural Regen Res. 2023 Feb;18(2):451-455. doi: 10.4103/1673-5374.346462.
Methylprednisolone pulse treatment is currently used for optic neuritis. It can speed visual recovery, but does not improve the ultimate visual outcomes. Recent studies have reported that miR-125a-5p has immunomodulatory effects on autoimmune diseases. However, it remains unclear whether miR-125a-5p has effects on optic neuritis. In this study, we used adeno-associated virus to overexpress or silence miR-125a-5p in mice. We found that silencing miR-125a-5p increased the latency of visual evoked potential and aggravated inflammation of the optic nerve. Overexpression of miR-125a-5p suppressed inflammation of the optic nerve, protected retinal ganglion cells, and increased the percentage of Treg cells. Our findings show that miR-125a-5p exhibits anti-inflammatory effects through promoting the differentiation of Treg cells.
甲基强的松龙脉冲治疗目前用于视神经炎。它可以加快视力恢复，但不能改善最终的视力结果。最近的研究报道，miR-125a-5p对自身免疫性疾病具有免疫调节作用。然而，miR-125a-5p对视神经炎是否有影响仍不清楚。在本研究中，我们使用腺相关病毒在小鼠中过表达或沉默miR-125a-5p。我们发现，沉默miR-125a-5p会增加视觉诱发电位的潜伏期，并加重视神经炎症。miR-125a-5p的过表达抑制了视神经炎症，保护了视网膜神经节细胞，并增加了调节性T细胞的百分比。我们的研究结果表明，miR-125a-5p通过促进调节性T细胞的分化发挥抗炎作用。
