辅助放疗治疗喉癌中微血管密度、VEGF 表达和神经周围侵犯的预后意义。

Prognostic importance of microvessel density, VEGF expression and perineural invasion in laryngeal cancer treated with adjuvant radiotherapy.

机构信息

Department of Radiation Oncology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.

Department of Radiation Oncology, Trakya University Medical Faculty, Edirne, Turkey.

出版信息

Indian J Pathol Microbiol. 2022 Jul-Sep;65(3):521-526. doi: 10.4103/ijpm.ijpm_655_21.

DOI:10.4103/ijpm.ijpm_655_21

PMID:35900477

Abstract

BACKGROUND AND AIMS

We aimed to investigate the prognostic importance of the microvessel density (MVD) value, the vascular endothelial growth factor (VEGF) expression, and the presence of perineural invasion (PNI) in laryngeal cancer (LSCC) patients.

METHODS

Pathological specimens of 62 LSCC patients were assessed for the evaluation of the MVD value, the VEGF expression level, and the presence of PNI of the tumors. The tumor characteristics and prognostic effects of these parameters on local control (LC) and overall survival (OS) were analyzed.

STATISTICAL ANALYSIS

Descriptive analyses were done using frequencies for the demographic variables. The survival estimates were calculated by the Kaplan-Meier survival curves. The effects of the parameters on LC and OS were investigated by using the log-rank test comparing the survival rates. Cox regression analysis was used for multivariable analysis.

RESULTS

The 5-year LC and OS rates of the 62 LSCC patients were 64.5 and 53.9%, respectively. Twenty-two patients (35.5%) had PNI and the frequency of PNI was higher in the patients with a high-grade disease (P = 0.01). The MVD value was higher in the tumors of older patients (P = 0.035) and was correlated with the VEGF expression (P = 0.009). A higher tumor grade was related to a higher VEGF expression (P = 0.01) and the increase in the VEGF expression was associated with a significant decrease in the OS (P = 0.03).

CONCLUSION

The VEGF expression, the MVD value, and the presence of PNI had no prognostic significance on the LC in the LSCC patients while only the VEGF expression was associated with the OS.

摘要

背景与目的

我们旨在探讨微血管密度（MVD）值、血管内皮生长因子（VEGF）表达以及神经周围侵犯（PNI）在喉癌（LSCC）患者中的预后意义。

方法

对 62 例 LSCC 患者的病理标本进行评估，以评估肿瘤的 MVD 值、VEGF 表达水平和 PNI 的存在情况。分析这些参数对局部控制（LC）和总生存（OS）的肿瘤特征和预后影响。

统计分析

使用频率对人口统计学变量进行描述性分析。通过 Kaplan-Meier 生存曲线计算生存估计值。通过比较生存率，使用对数秩检验研究参数对 LC 和 OS 的影响。使用 Cox 回归分析进行多变量分析。

结果

62 例 LSCC 患者的 5 年 LC 和 OS 率分别为 64.5%和 53.9%。22 例（35.5%）患者存在 PNI，高级别疾病患者的 PNI 频率更高（P=0.01）。MVD 值在老年患者的肿瘤中较高（P=0.035），且与 VEGF 表达呈正相关（P=0.009）。较高的肿瘤分级与较高的 VEGF 表达相关（P=0.01），VEGF 表达的增加与 OS 的显著降低相关（P=0.03）。