Department of Community Health & Psychiatry, The University of the West Indies, 3 Gibraltar Camp Way, Mona, Kingston 7, Jamaica.
Epidemiology Research Unit, Caribbean Institute for Health Research, The University of the West Indies, Mona, Kingston 7, Jamaica.
Qual Life Res. 2022 Dec;31(12):3391-3401. doi: 10.1007/s11136-022-03202-2. Epub 2022 Jul 28.
Prostate cancer (PCa) and its treatment can impact health-related quality of life (HRQoL). There are few studies of HRQoL in long-term PCa survivors of African ancestry from low- and middle-income countries. We examined the effect of PCa treatment on HRQoL of Jamaican PCa survivors compared with cancer-free controls and explored the effect of demographic and clinical factors on these outcomes.
PCa survivors (n = 64) treated with and without ADT along with PCa-free controls (n = 88) from a case-control study of 10 years post enrolment. HRQoL was measured using the European Organisation for Research and Treatment of Cancer Quality of Life (EORTC-QLQ-C30). Effects of demographic and clinical variables on HRQoL on PCa and type of therapy were evaluated in multivariable linear regression models.
HRQoL of PCa survivors (overall and by treatment group) indicated a high quality of life, comparable to PCa-free men. However, ADT-treated survivors had lower physical functioning that was of small clinical relevance compared with those not on ADT. Symptom burden scores of PCa survivors and controls were similar excluding fatigue and dyspnoea which were highest in men on ADT and controls. In multivariable models, PCa was not an important determinant of overall HRQoL, functioning or symptom burdens. Underlying medical conditions and marital status were the main contributors to HRQoL in PCa survivors.
PCa cancer status was not an independent determinant of long-term HRQoL in Jamaican men. Interventions addressing social factors and comorbid illnesses could improve HRQOL in long-term PCa survivors.
前列腺癌（PCa）及其治疗会影响健康相关生活质量（HRQoL）。来自中低收入国家的非洲裔 PCa 长期幸存者的 HRQoL 研究很少。我们研究了与无癌症对照相比，PCa 治疗对牙买加 PCa 幸存者的 HRQoL 的影响，并探讨了人口统计学和临床因素对这些结果的影响。
这项 10 年随访的病例对照研究纳入了接受 ADT 治疗和未接受 ADT 治疗的 PCa 幸存者（n=64）以及无癌症对照（n=88），使用欧洲癌症研究与治疗组织生活质量问卷（EORTC-QLQ-C30）测量 HRQoL。采用多变量线性回归模型评估人口统计学和临床变量对 PCa 和治疗类型对 HRQoL 的影响。
PCa 幸存者（总体和按治疗组）的 HRQoL 表明生活质量较高，与无癌症男性相当。然而，接受 ADT 治疗的幸存者的身体功能较低，与未接受 ADT 治疗的幸存者相比，这种差异具有较小的临床意义。除疲劳和呼吸困难外，PCa 幸存者和对照组的症状负担评分相似，ADT 治疗的男性和对照组的这些症状最严重。在多变量模型中，PCa 不是总体 HRQoL、功能或症状负担的重要决定因素。潜在的医疗状况和婚姻状况是 PCa 幸存者 HRQoL 的主要决定因素。
在牙买加男性中，PCa 状况不是长期 HRQoL 的独立决定因素。针对社会因素和合并疾病的干预措施可以改善长期 PCa 幸存者的 HRQoL。
