Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Elgomheryia street, Mansoura, 35511, Egypt.
Department of Diagnostic Radiology, Kafr Elsheak Faculty of Medicine, Kafrelsheikh, Egypt.
Oral Radiol. 2023 Apr;39(2):321-328. doi: 10.1007/s11282-022-00640-z. Epub 2022 Jul 28.
To evaluate arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) in discrimination of benign from malignant paranasal sinus (PNS) tumors.
A prospective study was done upon 42 cases of PNS masses that underwent magnetic resonance ASL and DWI of the head. Tumor blood flow (TBF) and apparent diffusion coefficient (ADC) of the masses were calculated by two observers. The pathological diagnosis was malignant (n = 28) and benign (n = 14) cases.
For both observers, the malignant PNS masses had significantly higher TBF (P < 0.001, 0.001) and lower ADC (P < 0.001, 0.001) than in benign masses. The ROC curve analysis of TBF, The threshed TBF was (121.45, 122.68 mL/100 g/min) used for differentiation between benign and malignant PNS masses, revealed sensitivity (92.9%, 89.3%), specificity (85.7%, 85.7%), accuracy (90.5%, 88.1%) and the AUC was 0.87 and 0.86 by both observers. the ROC curve analysis of ADC, The threshold ADC (1.215, 1.205 X10mm2/s) was used for differentiation between benign and malignant PNS masses, revealed sensitivity (96.4%, 89.3%), specificity (78.6%, 78.6%), accuracy of (90.5%, 85.7%) and the AUC was 0.93 and 0.92 by both observers. Combined analysis of TBF and ADC used for differentiation between benign and malignant PNS masses had revealed sensitivity (96.4%, 89.3%), specificity (92.9%, 85.7%) accuracy of (95.2%, 88.1%) and AUC. (0.995, 0.985) for both observers.
Combined using of TBF and ADC have a role in differentiation malignant from benign PNS masses.
评估动脉自旋标记（ASL）和弥散加权成像（DWI）在鉴别良恶性鼻窦（PNS）肿瘤中的作用。
前瞻性研究了 42 例鼻窦肿块患者，对其进行头部磁共振 ASL 和 DWI 检查。由两位观察者计算肿瘤血流（TBF）和肿块表观弥散系数（ADC）。病理诊断为恶性（n=28）和良性（n=14）病例。
对于两位观察者，恶性 PNS 肿块的 TBF 明显高于良性肿块（P<0.001，0.001），ADC 明显低于良性肿块（P<0.001，0.001）。TBF 的 ROC 曲线分析，用于鉴别良恶性 PNS 肿块的截断 TBF 为（121.45，122.68 mL/100 g/min），两位观察者的灵敏度分别为 92.9%和 89.3%，特异性分别为 85.7%和 85.7%，准确性分别为 90.5%和 88.1%，AUC 分别为 0.87 和 0.86。ADC 的 ROC 曲线分析，用于鉴别良恶性 PNS 肿块的截断 ADC 为（1.215，1.205 X10mm2/s），两位观察者的灵敏度分别为 96.4%和 89.3%，特异性分别为 78.6%和 78.6%，准确性分别为 90.5%和 85.7%，AUC 分别为 0.93 和 0.92。TBF 和 ADC 联合分析用于鉴别良恶性 PNS 肿块，两位观察者的灵敏度分别为 96.4%和 89.3%，特异性分别为 92.9%和 85.7%，准确性分别为 95.2%和 88.1%，AUC 分别为 0.995 和 0.985。
TBF 和 ADC 的联合应用有助于鉴别良恶性 PNS 肿块。
