Department of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19104, United States.
ACS Macro Lett. 2022 Aug 16;11(8):1022-1027. doi: 10.1021/acsmacrolett.2c00347. Epub 2022 Jul 28.
Crystalsomes are crystalline capsules that are formed by controlling polymer crystallization to break translational symmetry. While recent studies showed that these crystalline capsules exhibit interesting mechanical properties, thermal behavior, and excellent performance in blood circulation, the closed capsule is undesired for drug delivery applications. We report the formation and characterization of porous crystalsomes where porosity is rendered on the crystalline shells. A miniemulsion is formed using two amphiphilic block copolymers (BCP). The competition between controlled crystallization and phase separation of the BCPs at the emulsion surface leads to multiphase crystalsomes. Subsequently removing one BCP produces porous crystalline capsules.
晶体囊泡是通过控制聚合物结晶来打破平移对称性而形成的结晶胶囊。虽然最近的研究表明，这些结晶胶囊表现出有趣的机械性能、热行为和在血液循环中的优异性能，但对于药物输送应用来说，封闭的胶囊是不理想的。我们报告了多孔晶体囊泡的形成和特性，其中在结晶壳上形成了多孔性。使用两种两亲嵌段共聚物（BCP）形成了 miniemulsion。在乳液表面，受控结晶和 BCP 相分离之间的竞争导致多相晶体囊泡的形成。随后去除一种 BCP 会产生多孔结晶胶囊。
