Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 5 Koopertivny street, Tomsk, 634050, Russia.
Siberian State Medical University, 2, Moskovsky trakt, Tomsk, 634050, Russia.
Asian Pac J Cancer Prev. 2022 Jul 1;23(7):2191-2197. doi: 10.31557/APJCP.2022.23.7.2191.
The widespread infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) significantly impacts major human diseases. It is undoubtedly evident that cancer patients are more susceptible to the infection and at a higher risk of severe COVID-19 than the general population. Moreover, the rise in cancers incidence is waiting in the Globe as a long-term effect of post-COVID-19 complications. Multiple mostly unknown mechanisms participate and determine the oncogenic impact of virus-induced transformation. Imbalance in oncogenesis is considered critical in cancer development. Modified immunogenicity and metabolic features emerge as pivotal in COVID-19 pathogenesis and the organism system's response. The molecular mechanisms of the onset of the metabolic disorder have not yet been fully elucidated. The pathology is complicated, multifactorial, and emerging in various processes. Preventive anticancer therapy taking into account the change in metabolic processes, helps them respond better to anti-COVID-19 treatment than relying only on antiviral drugs. The modified therapeutic algorithm was provided to reduce the likelihood of post-acute complications in patients with preexisting pathologies and the onset of other chronic pathologies and cancers.
由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的广泛传染性疾病对人类主要疾病有重大影响。毫无疑问，癌症患者比一般人群更容易感染 SARS-CoV-2，并且患严重 COVID-19 的风险更高。此外，随着 COVID-19 并发症的长期影响，癌症发病率的上升正在全球范围内等待。多种大多未知的机制参与并决定病毒诱导转化的致癌作用。致癌失衡被认为是癌症发展的关键。免疫原性和代谢特征的改变成为 COVID-19 发病机制和机体系统反应的关键。代谢紊乱发病的分子机制尚未完全阐明。病理复杂，多因素，在各种过程中出现。考虑到代谢过程的变化，进行预防性抗癌治疗有助于患者更好地对抗 COVID-19 治疗，而不仅仅依赖于抗病毒药物。提供了改良的治疗方案，以降低患有既往疾病和其他慢性疾病和癌症的患者发生急性后并发症的可能性。
