Haagsma J
Tijdschr Diergeneeskd. 1987 May 15;112(10):579-86.
The current knowledge of the diagnosis and treatment of tuberculosis in cattle is reviewed as part of a series bearing the title 'Papers in the Past and Present'. A retrospective view is taken of the discovery of tuberculin by Robert Koch in 1890 and of three papers by Professor M.H.J.P. Thomassen, which appeared shortly after: 'Koch's Discovery and its Diagnostic Value to Veterinary Medicine'. A review of developments in the use of the tuberculin test and the methods used in the control of tuberculosis as well as reference to some bacteriological data is followed by a more detailed discussion of the pathogenesis and immunology of tuberculosis. The current epidemiological situation and disease control are then discussed. Attention is drawn to the importance of using high-grade standardized forms of tuberculin. The complicated nature of the chemical formula and immunological characteristics of tuberculin, including modern forms of PPD tuberculin, are commented upon, and the paper is concluded with a look into the future regarding modern diagnostic prospects such as the development of synthetically manufactured tuberculin, the use of specific monoclonal antibodies and specific DNA probes.
作为“过去与现在的论文”系列的一部分，本文回顾了当前牛结核病诊断和治疗的相关知识。文章对1890年罗伯特·科赫发现结核菌素进行了回顾，并提及了M.H.J.P. 托马森教授随后发表的三篇论文：《科赫的发现及其对兽医学的诊断价值》。在回顾结核菌素试验的应用发展、结核病控制方法以及一些细菌学数据之后，文章更详细地讨论了结核病的发病机制和免疫学。接着讨论了当前的流行病学情况和疾病控制。文中强调了使用高质量标准化结核菌素的重要性。对结核菌素的化学式复杂性和免疫特性进行了评论，包括现代形式的纯蛋白衍生物（PPD）结核菌素。文章最后展望了未来的现代诊断前景，如合成制造结核菌素的发展、特异性单克隆抗体和特异性DNA探针的应用。
