Chen Yutong, Zhao Siqiao, Kang Yihan, Zhang Yuelin, Chang Xu
Department of Surgical Oncology, Breast Surgery, General Surgery, First Affiliated Hospital of China Medical University, No. 77 PuHe Road, Shenyang North New Area, Shenyang 110122, China.
Department of Anesthesiology, Shengjing Hospital of China Medical University, No. 77 PuHe Road, Shenyang North New Area, Shenyang 110122, China.
Biochim Biophys Acta Mol Cell Res. 2022 Nov;1869(11):119328. doi: 10.1016/j.bbamcr.2022.119328. Epub 2022 Jul 25.
Ferroptosis is a unique iron-dependent cell death mechanism characterized by the generation of lipid reactive oxygen species (ROS) in cancer cells, which leads to mitochondrial metabolic dysregulation. However, how could the tumor immune microenvironment (TIME) modulates ferroptosis remains unclear. Thus, by integrating multiple algorithms, we revealed the novel functional and immune patterns of the ferroptosis-related genes (FRGs) in breast cancer. Five prognostic FRGs were finally selected for the prognostic signature and four of which were identified as the independent biomarkers for immunotherapies. The consensus cluster analysis illustrated the FRGs were characterized by the metabolism dysfunction and immune infiltration cells, meanwhile, these FRGs have the same stem cell characteristics and response efficacy to the immunotherapies. In conclusion, a comprehensive analysis of the FRGs in breast cancer was conducted to develop a prognostic gene signature. Functional and immunological evidence of vulnerabilities in the interaction between ferroptosis and the TIME was also revealed. Further data and research are required.
铁死亡是一种独特的铁依赖性细胞死亡机制，其特征是癌细胞中产生脂质活性氧（ROS），这会导致线粒体代谢失调。然而，肿瘤免疫微环境（TIME）如何调节铁死亡仍不清楚。因此，通过整合多种算法，我们揭示了乳腺癌中铁死亡相关基因（FRGs）的新功能和免疫模式。最终选择了五个预后FRGs用于预后特征分析，其中四个被确定为免疫治疗的独立生物标志物。共识聚类分析表明，FRGs的特征是代谢功能障碍和免疫浸润细胞，同时，这些FRGs具有相同的干细胞特征和对免疫治疗的反应效果。总之，对乳腺癌中的FRGs进行了综合分析，以开发一种预后基因特征。还揭示了铁死亡与TIME之间相互作用中脆弱性的功能和免疫学证据。还需要进一步的数据和研究。
