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明胶基水凝胶(GHs)在环境、技术和生物医学领域的制备、性质及应用

Preparation, properties, and applications of gelatin-based hydrogels (GHs) in the environmental, technological, and biomedical sectors.

作者信息

Mushtaq Farwa, Raza Zulfiqar Ali, Batool Syeda Rubab, Zahid Muhammad, Onder Ozgun Can, Rafique Ammara, Nazeer Muhammad Anwaar

机构信息

School of Engineering and Technology, National Textile University, Faisalabad, Pakistan; School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei, China.

Department of Applied Sciences, National Textile University, Faisalabad, Pakistan.

出版信息

Int J Biol Macromol. 2022 Oct 1;218:601-633. doi: 10.1016/j.ijbiomac.2022.07.168. Epub 2022 Jul 25.

Abstract

Gelatin's versatile functionalization offers prospects of facile and effective crosslinking as well as combining with other materials (e.g., metal nanoparticles, carbonaceous, minerals, and polymeric materials exhibiting desired functional properties) to form hybrid materials of improved thermo-mechanical, physio-chemical and biological characteristics. Gelatin-based hydrogels (GHs) and (nano)composite hydrogels possess unique functional features that make them appropriate for a wide range of environmental, technical, and biomedical applications. The properties of GHs could be balanced by optimizing the hydrogel design. The current review explores the various crosslinking techniques of GHs, their properties, composite types, and ultimately their end-use applications. GH's ability to absorb a large volume of water within the gel network via hydrogen bonding is frequently used for water retention (e.g., agricultural additives), and absorbency towards targeted chemicals from the environment (e.g., as wound dressings for absorbing exudates and in water treatment for absorbing pollutants). GH's controllable porosity makes its way to be used to restrict access to chemicals entrapped within the gel phase (e.g., cell encapsulation), regulate the release of encapsulated cargoes within the GH (e.g., drug delivery, agrochemicals release). GH's soft mechanics closely resembling biological tissues, make its use in tissue engineering to deliver suitable mechanical signals to neighboring cells. This review discussed the GHs as potential materials for the creation of biosensors, drug delivery systems, antimicrobials, modified electrodes, water adsorbents, fertilizers and packaging systems, among many others. The future research outlooks are also highlighted.

摘要

明胶具有多种功能化特性,为简便有效的交联以及与其他材料(如具有所需功能特性的金属纳米颗粒、含碳材料、矿物质和聚合物材料)结合提供了前景,从而形成具有改善的热机械、物理化学和生物学特性的杂化材料。基于明胶的水凝胶(GHs)和(纳米)复合水凝胶具有独特的功能特性,使其适用于广泛的环境、技术和生物医学应用。通过优化水凝胶设计,可以平衡GHs的性能。本综述探讨了GHs的各种交联技术、它们的性能、复合类型以及最终的终端应用。GHs通过氢键在凝胶网络中吸收大量水分的能力常用于保水(如农业添加剂),以及从环境中吸收目标化学物质(如作为吸收渗出液的伤口敷料和用于吸收污染物的水处理)。GHs可控的孔隙率使其可用于限制对凝胶相中捕获的化学物质的接触(如细胞封装),调节GHs中封装货物的释放(如药物递送、农用化学品释放)。GHs类似于生物组织的柔软力学性能,使其可用于组织工程,向邻近细胞传递合适的机械信号。本综述讨论了GHs作为创建生物传感器、药物递送系统、抗菌剂、修饰电极、水吸附剂、肥料和包装系统等众多潜在材料的情况。还强调了未来的研究展望。

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