海湾战争病的疲劳和疼痛严重程度与炎症细胞因子和阳性急性期蛋白的变化有关。
Fatigue and Pain Severity in Gulf War Illness Is Associated With Changes in Inflammatory Cytokines and Positive Acute Phase Proteins.
机构信息
From the Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama.
出版信息
J Occup Environ Med. 2022 Nov 1;64(11):905-911. doi: 10.1097/JOM.0000000000002625. Epub 2022 Jul 28.
OBJECTIVE
The aim of the study is to investigate relationships between inflammatory analytes and symptoms of pain and fatigue in Gulf War illness (GWI).
METHODS
In this preliminary study, 12 male veterans meeting GWI criteria provided daily blood samples and symptom ratings over 25 days. Linear mixed models were used to analyze associations between symptoms and sera concentrations of cytokines, acute phase proteins, insulin, and brain-derived neurotropic factor.
RESULTS
Analyses included 277 days with both blood draws and self-reports. Days with worse fatigue severity were associated with higher C-reactive protein and serum amyloid A, and lower eotaxin 1. Muscle pain and joint pain were associated with leptin, monocyte chemoattractant protein 1, and interferon γ-induced protein. Joint pain was further associated with serum amyloid A and eotaxin 3.
CONCLUSIONS
Gulf War illness involves fatigue and pain associated with inflammation. Conventional and novel anti-inflammatories should be further explored for the treatment of GWI.
目的
本研究旨在探讨海湾战争病（GWI）患者炎症分析物与疼痛和疲劳症状之间的关系。
方法
在这项初步研究中，12 名符合 GWI 标准的男性退伍军人在 25 天内每天提供血液样本和症状评分。线性混合模型用于分析症状与细胞因子、急性期蛋白、胰岛素和脑源性神经营养因子的血清浓度之间的关系。
结果
分析包括 277 天同时进行血液采集和自我报告。疲劳严重程度较高的天数与 C 反应蛋白和血清淀粉样蛋白 A 升高以及嗜酸性粒细胞趋化因子 1 降低有关。肌肉疼痛和关节疼痛与瘦素、单核细胞趋化蛋白 1 和干扰素 γ 诱导蛋白有关。关节疼痛与血清淀粉样蛋白 A 和嗜酸性粒细胞趋化因子 3 进一步相关。
结论
海湾战争病涉及与炎症相关的疲劳和疼痛。应进一步探索常规和新型抗炎药治疗 GWI。
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