Baris Elif, Topaloglu Izel, Akalin Elif, Hamurtekin Emre, Kabaran Seray, Gelal Ayse, Ucku Reyhan, Arici Mualla Aylin
Izmir University of Economics, Faculty of Medicine, Department of Medical Pharmacology, Izmir, Turkey.
Dokuz Eylul University Faculty of Medicine, Department of Physical Therapy and Rehabilitation, Izmir, Turkey.
BMC Musculoskelet Disord. 2025 Feb 1;26(1):97. doi: 10.1186/s12891-025-08337-0.
Fibromyalgia Syndrome (FMS) predominantly affects middle-aged women, characterized by musculoskeletal pain, fatigue, and cognitive issues. Choline, an endogenous molecule, may influence FMS due to its analgesic and anti-inflammatory properties. This study compared choline, leptin, and interleukin-6 (IL-6) levels in FMS patients and controls and examining their association with pain severity.
Volunteers with FMS were clinically diagnosed at a Physical Medicine and Rehabilitation Department. The control group included pain-free volunteers. Pain severity was gauged using a numeric scale, dietary choline intake through a questionnaire. Serum choline, leptin and (interleukin)IL-6 levels were measured from fasting blood samples of volunteers with enzyme-linked immunosorbent assays (ELISA).
All FMS patients (n = 38) and healthy volunteers (n = 38) were female. Pain score in patients with FMS was 7.6 ± 0.2. Dietary choline intake was lower in patients with FMS than the controls (p = 0.036). Serum choline and leptin levels were lower in the FMS group compared to control (p = 0.03). Serum IL-6 levels were higher in the FMS group than in the control (p < 0.001). There was weak positive correlation between IL-6 levels and pain scores and there were no correlation between leptin levels and pain scores in FMS.
This research highlights FMS's complex nature, involving neurochemical, immunological, and nutritional factors. It suggests the significance of choline's anti-inflammatory effect, leptin's metabolic function, and IL-6's role in FMS pathology. The results suggest that reduced dietary choline might influence serum choline, leptin, and IL-6 levels, potentially impacting FMS-related pain. This points to the potential of supplementary choline intake in FMS management.
Not applicable (Non-interventional study).
纤维肌痛综合征（FMS）主要影响中年女性，其特征为肌肉骨骼疼痛、疲劳和认知问题。胆碱作为一种内源性分子，因其镇痛和抗炎特性可能会对纤维肌痛综合征产生影响。本研究比较了纤维肌痛综合征患者和对照组中胆碱、瘦素和白细胞介素-6（IL-6）的水平，并研究了它们与疼痛严重程度的关联。
在物理医学与康复科对患有纤维肌痛综合征的志愿者进行临床诊断。对照组包括无疼痛的志愿者。使用数字评分量表评估疼痛严重程度，通过问卷评估饮食中胆碱的摄入量。采用酶联免疫吸附测定法（ELISA）从志愿者的空腹血样中检测血清胆碱、瘦素和白细胞介素（IL-6）水平。
所有纤维肌痛综合征患者（n = 38）和健康志愿者（n = 38）均为女性。纤维肌痛综合征患者的疼痛评分为7.6±0.2。纤维肌痛综合征患者的饮食胆碱摄入量低于对照组（p = 0.036）。与对照组相比，纤维肌痛综合征组的血清胆碱和瘦素水平较低（p = 0.03）。纤维肌痛综合征组的血清IL-6水平高于对照组（p < 0.001）。纤维肌痛综合征患者中，IL-水平与疼痛评分之间存在弱正相关，瘦素水平与疼痛评分之间无相关性。
本研究突出了纤维肌痛综合征的复杂性，涉及神经化学、免疫和营养因素。这表明胆碱的抗炎作用、瘦素的代谢功能以及IL-6在纤维肌痛综合征病理过程中的作用具有重要意义。结果表明，饮食中胆碱摄入减少可能会影响血清胆碱、瘦素和IL-6水平，进而可能影响与纤维肌痛综合征相关的疼痛。这表明补充胆碱摄入在纤维肌痛综合征管理中具有潜力。
不适用（非干预性研究）。
