This up-to-date review focused on the recent advances in the concept, interrelationship, and mechanisms of the polytrauma clinical triad (PCT), and intervention knowledge and approaches to its prevention and treatment from the perspective of military pain medicine, hoping to provide a scientific basis and reference of PCT. Many soldiers suffering from chronic pain coexist with post-traumatic stress disorder and traumatic brain injury. If the above three diseases exist, it is called PCT. Three diseases in this common triad are interrelated and reinforce each other. This triad is challenging to treat and often leads to chronic issues, especially if not adequately monitored and managed. Although each disease of this triad could occur in isolation, it is valuable to know whether the rest of PCT needs to be screened. Current treatment of this triad emphasizes accurate identification and assessment of each disease, the new interdisciplinary and multimodal system of care, individualized customization principles, and shared medical decisions. To maximize clinical success and military service, interdisciplinary providers may benefit from the joint development of complementary treatment and biopsychosocial approach supported by theoretical and empirical evidence. The management of the PCT should emphasize integrative medicine and new interdisciplinary, multimodal nursing. Furthermore, cognitive behavioral therapy, standard rehabilitation care, and integrated health therapy have yielded valuable efficacy. It also should encourage the establishment of harmonious treatment relationships, shared medical decisions, and individualized customization principles to care for military service members with these comorbidities.