Department of Psychology, Middle Tennessee State University, Murfreesboro, TN, USA.
Center for Neuro-Restoration, Cleveland Clinic Foundation, Cleveland, OH, USA.
Adv Exp Med Biol. 2022;1378:155-178. doi: 10.1007/978-3-030-99550-8_11.
It has been well demonstrated that the cerebellum is associated with cognitive and affective processing as well as the traditionally conceptualized motor function. In the present chapter, we explore the behavioral and neurobiological implications of a common congenital cerebellar condition, Chiari malformation Type I, on cognitive and affective processing. We also emphasize the associations between Chiari-related chronic pain, cognitive dysfunction, and emotion dysregulation. Based on our review of the literature, we argue that chronic pain can account for a substantial amount of the cognitive dysfunction and emotion dysregulation in Chiari malformation Type I. Yet, there also exists aspects of Chiari-related cognitive dysfunction and emotion dysregulation that appear to be at least partially independent of chronic pain and more directly associated with abnormalities in cerebrospinal fluid flow dynamics and cerebro-cerebellar communication pathways.
已经充分证明，小脑与认知和情感处理以及传统意义上的运动功能有关。在本章中，我们探讨了一种常见的先天性小脑疾病——Chiari 畸形 I 型对认知和情感处理的行为和神经生物学影响。我们还强调了 Chiari 相关慢性疼痛、认知功能障碍和情绪失调之间的关联。基于我们对文献的回顾，我们认为慢性疼痛可以解释 Chiari 畸形 I 型中大量的认知功能障碍和情绪失调。然而，Chiari 相关认知功能障碍和情绪失调的某些方面似乎至少部分独立于慢性疼痛，而与脑脊液流动动力学和脑-小脑通讯途径的异常更直接相关。
