A randomized, placebo-controlled, double-blinded pilot study of angiotensin 1-7 (TXA-127) for the treatment of severe COVID-19.
作者信息
Wagener Gebhard, Goldklang Monica P, Gerber Adam, Elisman Katerina, Eiseman Katherine A, Fonseca Laura D, D'Armiento Jeanine M
机构信息
Department of Anesthesiology, Columbia University Irving Medical Center, 622 West 168th Street, PH 5, New York, NY, 10032, USA.
Columbia University Vagelos College of Physicians and Surgeons, New York-Prebysterian Columbia University Medical Center, 630 West 168th Street, New York, NY, 10032, USA.
出版信息
Crit Care. 2022 Jul 28;26(1):229. doi: 10.1186/s13054-022-04096-9.
Abstract
摘要
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Cancer Chemother Pharmacol. 2013 Apr;71(4):965-72. doi: 10.1007/s00280-013-2089-x. Epub 2013 Jan 31.
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Lentivirus-mediated overexpression of angiotensin-(1-7) attenuated ischaemia-induced cardiac pathophysiology.慢病毒介导的血管紧张素-(1-7)过表达减轻缺血诱导的心脏病理生理学改变。
Exp Physiol. 2011 Sep;96(9):863-74. doi: 10.1113/expphysiol.2011.056994. Epub 2011 Jun 17.
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The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension.血管紧张素转化酶 2/血管生成素-(1-7)/Mas 轴赋予心肺对肺纤维化和肺动脉高压的保护作用。
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