Yu Mujun, Yu Haozhen, Mu Nan, Wang Yishi, Ma Heng, Yu Lu
School of Life Sciences, Yan'an University, Yan'an, China.
School of Basic Medical Sciences, Shaanxi University of Traditional Chinese Medicine, Xianyang, China.
Front Physiol. 2022 Jul 12;13:928625. doi: 10.3389/fphys.2022.928625. eCollection 2022.
Forkhead box (FOX) transcription factors play a crucial role in the regulation of many diseases, being an evolutionarily conserved superfamily of transcription factors. In recent years, FoxK1/2, members of its family, has been the subject of research. Even though FoxK1 and FoxK2 have some functional overlap, increasing evidence indicates that the regulatory functions of FoxK1 and FoxK2 are not the same in various physiological and disease states. It is important to understand the biological function and mechanism of FoxK1/2 for better understanding pathogenesis of diseases, predicting prognosis, and finding new therapeutic targets. There is, however, a lack of comprehensive and systematic analysis of the similarities and differences of FoxK1/2 roles in disease, prompting us to perform a literature review.
叉头框（FOX）转录因子是一类进化上保守的转录因子超家族，在多种疾病的调控中发挥着关键作用。近年来，其家族成员FoxK1/2成为了研究对象。尽管FoxK1和FoxK2存在一些功能重叠，但越来越多的证据表明，在各种生理和疾病状态下，FoxK1和FoxK2的调控功能并不相同。了解FoxK1/2的生物学功能和机制对于更好地理解疾病发病机制、预测预后以及寻找新的治疗靶点至关重要。然而，目前缺乏对FoxK1/2在疾病中作用异同的全面系统分析，这促使我们进行了一项文献综述。
