Nutmakul Thanutchaporn
Graduate Program in Nutrition, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Ratchatewi, Bangkok, 10400, Thailand.
Saudi Pharm J. 2022 Jul;30(7):918-926. doi: 10.1016/j.jsps.2022.04.013. Epub 2022 Apr 30.
Hyperuricemia becomes a public health problem worldwide. It is not only a major risk factor for gout but also associated with the development of life-threatening diseases such as chronic kidney disease and cardiovascular diseases. Although there are several available therapeutic drugs, some serious adverse effects and contraindications are concerned. These drive the search for an alternative therapy that is effective and safe. Quercetin is of particular interesting since it has been reported numerous pharmacological activities, especially anti-hyperuricemia, antioxidant, anti-inflammation and amelioration of metabolic syndromes and cardiovascular diseases which are comorbidities of hyperuricemia and gout. In addition, quercetin has been widely used as a health supplement for many diseases however, the use for hyperuricemia and gout has not been indicated. Therefore, this review aims to gather and summarize published data regarding the efficacy in preclinical and clinical studies along with possible mechanism of action, and safety aspect of quercetin in order to support the use of quercetin as a dietary supplement for prevention and management of hyperuricemia and gouty arthritis and/or use as alternative or combination therapy to minimize the side effects of the conventional drugs.
高尿酸血症已成为一个全球性的公共卫生问题。它不仅是痛风的主要危险因素，还与诸如慢性肾病和心血管疾病等危及生命的疾病的发生有关。尽管有几种可用的治疗药物，但仍存在一些严重的不良反应和禁忌症。这些促使人们寻找一种有效且安全的替代疗法。槲皮素特别引人关注，因为它已被报道具有多种药理活性，尤其是抗高尿酸血症、抗氧化、抗炎以及改善代谢综合征和心血管疾病等高尿酸血症和痛风的合并症。此外，槲皮素已被广泛用作许多疾病的健康补充剂，然而，其在高尿酸血症和痛风方面的应用尚未得到明确。因此，本综述旨在收集和总结已发表的关于槲皮素在临床前和临床研究中的疗效、可能的作用机制以及安全性方面的数据，以支持将槲皮素用作预防和管理高尿酸血症和痛风性关节炎的膳食补充剂，和/或用作替代疗法或联合疗法以尽量减少传统药物的副作用。
