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前列腺癌:是否需要积极治疗?

Cancer of the prostate: is there a need for aggressive treatment?

作者信息

Moskovitz B, Nitecki S, Richter Levin D

出版信息

Urol Int. 1987;42(1):49-52. doi: 10.1159/000281849.

DOI:10.1159/000281849
PMID:3590404
Abstract

Adenocarcinoma of the prostate constitutes 18% of all cancers in men, and is a major cause of neoplastic death second only to carcinoma of lungs and large bowel. In spite of the high incidence of the disease, there is still disagreement as to the right treatment. In our study we reviewed 101 patients in stages T0b, T1 + T2, T3 (N0M0) who were treated by nonradical prostatectomy and no other treatment. The follow-up of these patients was 58 months. The actuarial 5- and 10-year survival according to stage was respectively: 91.30 and 64.62% in stage T0b; 60.61 and 34.11% in stage T1 + T2, and 41.67% in stage T3. Survival rates resembled those quoted in the literature. Our results justify a less aggressive approach to carcinoma of the prostate.

摘要

前列腺腺癌占男性所有癌症的18%,是仅次于肺癌和大肠癌的肿瘤性死亡的主要原因。尽管该疾病发病率很高,但对于正确的治疗方法仍存在分歧。在我们的研究中,我们回顾了101例处于T0b、T1 + T2、T3(N0M0)期的患者,这些患者接受了非根治性前列腺切除术且未接受其他治疗。对这些患者的随访时间为58个月。根据分期,精算的5年和10年生存率分别为:T0b期为91.30%和64.62%;T1 + T2期为60.61%和34.11%,T3期为41.67%。生存率与文献中引用的相似。我们的结果证明对前列腺癌采取较不积极的治疗方法是合理的。

相似文献

1
Cancer of the prostate: is there a need for aggressive treatment?前列腺癌:是否需要积极治疗?
Urol Int. 1987;42(1):49-52. doi: 10.1159/000281849.
2
Differential post-prostatectomy cancer-specific survival of occult T3 vs. clinical T3 prostate cancer: Implications for managing patients upstaged on prostate magnetic resonance imaging.隐匿性T3期与临床T3期前列腺癌前列腺切除术后癌症特异性生存差异:对前列腺磁共振成像分期上调患者管理的启示
Urol Oncol. 2015 Jul;33(7):330.e19-25. doi: 10.1016/j.urolonc.2015.03.010. Epub 2015 May 16.
3
Long-term results of radical retropubic prostatectomy in men with high grade carcinoma of the prostate.耻骨后根治性前列腺切除术治疗前列腺高级别癌男性患者的长期结果
J Urol. 1997 Oct;158(4):1460-5.
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Stage D1 (T1-3, N1-3, M0) prostate cancer: a case-controlled comparison of conservative treatment versus radical prostatectomy.D1期(T1 - 3,N1 - 3,M0)前列腺癌:保守治疗与根治性前列腺切除术的病例对照比较
Urology. 1997 Aug;50(2):251-5. doi: 10.1016/S0090-4295(97)00186-6.
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Radical prostatectomy for clinical stage T3a disease.针对临床分期为T3a期疾病的根治性前列腺切除术。
Cancer. 2007 Apr 1;109(7):1273-8. doi: 10.1002/cncr.22544.
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Time trends in case selection, stage and prostate-specific antigen recurrence after radical prostatectomy: a multicentre audit.根治性前列腺切除术后病例选择、分期及前列腺特异性抗原复发的时间趋势:一项多中心审计
BJU Int. 2004 Apr;93(6):725-9. doi: 10.1111/j.1464-410X.2003.04715.x.
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Radiation therapy for T1 and T2 prostate cancer: prostate-specific antigen and disease outcome.T1和T2期前列腺癌的放射治疗:前列腺特异性抗原与疾病转归
Urology. 1995 Mar;45(3):476-83. doi: 10.1016/S0090-4295(99)80019-3.
8
Primary surgical therapy for clinical stage T3 adenocarcinoma of the prostate.前列腺临床分期为T3腺癌的原发性手术治疗。
Semin Urol Oncol. 1997 Nov;15(4):215-21.
9
Management of stage pTxN+ adenocarcinoma of the prostate: influence of radical prostatectomy on progression-free interval.前列腺pTxN+期腺癌的管理:根治性前列腺切除术对无进展生存期的影响。
Zhonghua Yi Xue Za Zhi (Taipei). 1999 Aug;62(8):514-20.
10
Lymphovascular invasion is an independent prognostic factor in prostatic adenocarcinoma.淋巴管浸润是前列腺腺癌的一个独立预后因素。
J Urol. 2005 Dec;174(6):2181-5. doi: 10.1097/01.ju.0000181215.41607.c3.

引用本文的文献

1
Prostate cancer: 2. Natural history.前列腺癌:2. 自然病史。
CMAJ. 1998 Sep 22;159(6):685-91.
2
Attitude of African-Americans regarding prostate cancer clinical trials.非裔美国人对前列腺癌临床试验的态度。
J Community Health. 1996 Apr;21(2):77-87. doi: 10.1007/BF01682300.
3
Prevention. How much harm? How much benefit? 2. Ten potential pitfalls in determining the clinical significance of benefits.预防。有多大危害?有多大益处?2. 确定益处临床意义时的十个潜在陷阱。
CMAJ. 1996 Jun 15;154(12):1837-43.