Department of Ophthalmology, Shanghai Xuhui Central Hospital, Shanghai 200031, P.R. China.
Department of Laboratory, Shanghai Xuhui Central Hospital, Shanghai 200031, P.R. China.
Mol Med Rep. 2022 Sep;26(3). doi: 10.3892/mmr.2022.12807. Epub 2022 Jul 29.
Immunoglobulins serve immunomodulatory roles in numerous autoimmune diseases. The aim of the present study was to investigate the correlations between serum Ig levels and retinal structural parameters in patients with newly diagnosed acute Vogt‑Koyanagi‑Harada (VKH) disease. A total of 138 participants were enrolled and the foveal thickness (FT), serous retinal detachment (SRD), sensory retinal thickness, central FT (CFT), cube volume (V) and cube average thickness (AT) were assessed by optical coherence tomography. The patients were divided, according to the extent of SRD, into a high‑detachment group (>500 µm) and a low‑detachment group (≤500 µm). Rate‑scattering turbidimetry was performed to measure the Ig levels. The high‑detachment group comprised 51 (36.96%) patients. The proportion of males was significantly greater in the high‑detachment group compared with the low‑detachment group (58.82 vs. 40.23%; P<0.05) and best‑corrected visual acuity was significantly worse in the high‑detachment group compared with the low‑detachment group (P<0.001). The IgE levels in the high‑detachment group were significantly greater compared with the low‑detachment group (P<0.05). FT, SRD, CFT, V and AT were significantly greater in the high‑detachment group compared with the low‑detachment group (P<0.001). The IgE levels were positively associated with SRD, CFT and AT (P<0.05). Multivariate binary logistic regression analysis demonstrated that male sex (B=2.447; P<0.05) and serum IgE levels (B=0.997, P<0.05) may be independent risk factors for severe SRD. The results of the present study demonstrated that males are more likely to develop severe SRD and that serum IgE levels were associated with the extent of detachment. These data suggested that IgE may be involved in the progression of VKH disease.
免疫球蛋白在许多自身免疫性疾病中发挥免疫调节作用。本研究旨在探讨初诊急性 Vogt-Koyanagi-Harada（VKH）病患者血清 Ig 水平与视网膜结构参数之间的相关性。共纳入 138 例患者，采用光学相干断层扫描评估患者的中心凹视网膜厚度（FT）、浆液性视网膜脱离（SRD）、感觉性视网膜厚度、中心 FT（CFT）、立方体积（V）和立方平均厚度（AT）。根据 SRD 的范围，患者被分为高脱离组（>500μm）和低脱离组（≤500μm）。速率散射比浊法用于测量 Ig 水平。高脱离组 51 例（36.96%）。与低脱离组相比，高脱离组男性比例显著更高（58.82%比 40.23%，P<0.05），最佳矫正视力显著更差（P<0.001）。与低脱离组相比，高脱离组 IgE 水平显著更高（P<0.05）。与低脱离组相比，高脱离组 FT、SRD、CFT、V 和 AT 均显著更大（P<0.001）。IgE 水平与 SRD、CFT 和 AT 呈正相关（P<0.05）。多变量二元逻辑回归分析表明，男性（B=2.447，P<0.05）和血清 IgE 水平（B=0.997，P<0.05）可能是严重 SRD 的独立危险因素。本研究结果表明，男性更易发生严重 SRD，血清 IgE 水平与脱离程度相关。这些数据表明 IgE 可能参与 VKH 病的进展。
