ER stress and Mucosal Immunology Laboratory, School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.
Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Biotechnol Genet Eng Rev. 2023 Apr;39(1):143-165. doi: 10.1080/02648725.2022.2106002. Epub 2022 Jul 29.
Glioblastoma (GBM) is presented with a poor prognosis. The endoplasmic reticulum stress (ERS) has been implicated as a major contributor to disease progression and chemoresistance in GBM. Triggering ERS by chemical agents or genetic modulations is identified as some of the reasons for regulating gene expression and the pathogenesis of GBM. ERS initiates unfolded protein response (UPR), an integrated system useful in restoring homeostasis or inducing apoptosis. Modulation of UPR might have positive outcomes in GBM treatment as UPR inducers have been shown to alter cell survival and migration. In the current review, we have utilized GSE7806, a publicly available dataset from Gene Expression Omnibus (GEO), to evaluate the genes expressed during 6.5 hr and 18 hr, which can be comparable to the early and late-onset of the disease. Subsequently, we have elucidated the prognosis and survival information whilst the expression of these genes in the GBM was noted in previous studies. This is the first of its kind review summarizing the most recent gene information correlating UPR and GBM.
胶质母细胞瘤（GBM）预后较差。内质网应激（ERS）被认为是导致 GBM 疾病进展和化疗耐药的主要因素。化学试剂或遗传修饰触发 ERS 被认为是调节基因表达和 GBM 发病机制的部分原因。ERS 启动未折叠蛋白反应（UPR），这是一种有助于恢复体内平衡或诱导细胞凋亡的综合系统。UPR 的调节可能对 GBM 治疗有积极的结果，因为已经证明 UPR 诱导剂可以改变细胞的存活和迁移。在本综述中，我们利用了基因表达综合数据库（GEO）中公开的 GSE7806 数据集，来评估在 6.5 小时和 18 小时期间表达的基因，这可以与疾病的早期和晚期相媲美。随后，我们阐明了预后和生存信息，同时也注意到了之前研究中这些基因在 GBM 中的表达。这是首例总结 UPR 和 GBM 最新基因信息相关性的综述。
