• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

中药防治蒽环类药物所致肿瘤患者心脏毒性的作用：前瞻性研究的荟萃分析。

Cardioprotective effect of Chinese herbal medicine for anthracycline-induced cardiotoxicity in cancer patients: A meta-analysis of prospective studies.

机构信息

Department of Breast Surgery (Integrated Traditional and Western Medicine), Long Hua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Shanghai University of Traditional Chinese Medicine, Shanghai, China.

出版信息

Medicine (Baltimore). 2022 Jul 29;101(30):e29691. doi: 10.1097/MD.0000000000029691.

DOI:10.1097/MD.0000000000029691
PMID:35905252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9333524/
Abstract

BACKGROUND

To assess the benefits and harmful effects of Chinese herbal medicine (CHM) formulations in preventing anthracyclines (ANT)-induced cardiotoxicity.

METHOD

The Cochrane Library, Pubmed and EMBASE databases were electronically searched for relevant randomized controlled trials (RCTs) published till December 2021 in English or Chinese-language, in addition to manual searches through the reference lists of the selected papers, and the Chinese Conference Papers Database. Data was extracted by 2 investigators independently.

RESULT

Seventeen RCTs reporting 11 different CHMs were included in this meta-analysis. The use of CHM reduced the occurrence of clinical heart failure (RR 0.48, 95% CI 0.39 to 0.60, P < .01) compared to the control group. Data on subclinical heart failure in terms of LVEF values showed that CHM reduced the occurrence of subclinical heart failure (RR 0.47, 95% CI 0.35 to 0.62, P < .01) as well.

CONCLUSION

CHM is an effective and safe cardioprotective intervention that can potentially prevent ANT-induced cardiotoxicity. However, due to the insufficient quality of the included trials, our results should be interpreted with cautious.

摘要

背景

评估中草药（CHM）制剂预防蒽环类药物（ANT）诱导性心脏毒性的益处和有害影响。

方法

电子检索 Cochrane 图书馆、Pubmed 和 EMBASE 数据库中截至 2021 年 12 月以英文或中文发表的相关随机对照试验（RCT），此外还通过对选定论文的参考文献列表以及中国会议论文数据库进行手工检索。由 2 名调查员独立提取数据。

结果

这项荟萃分析纳入了 17 项 RCT，报告了 11 种不同的 CHM。与对照组相比，使用 CHM 可降低临床心力衰竭的发生（RR 0.48，95%CI 0.39 至 0.60，P<.01）。关于左心室射血分数（LVEF）值的亚临床心力衰竭的数据表明，CHM 也可降低亚临床心力衰竭的发生（RR 0.47，95%CI 0.35 至 0.62，P<.01）。

结论

CHM 是一种有效且安全的心脏保护干预措施，可能预防 ANT 诱导性心脏毒性。然而，由于纳入试验的质量不足，我们的结果应谨慎解释。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/ebeafd5a8604/medi-101-e29691-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/3afd196ca454/medi-101-e29691-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/8e72ad601825/medi-101-e29691-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/9fcc049d617c/medi-101-e29691-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/b3d2480c32cb/medi-101-e29691-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/53244f3beafa/medi-101-e29691-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/7641d21baf16/medi-101-e29691-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/122cded3104f/medi-101-e29691-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/14fe0b8f46ff/medi-101-e29691-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/ebeafd5a8604/medi-101-e29691-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/3afd196ca454/medi-101-e29691-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/8e72ad601825/medi-101-e29691-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/9fcc049d617c/medi-101-e29691-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/b3d2480c32cb/medi-101-e29691-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/53244f3beafa/medi-101-e29691-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/7641d21baf16/medi-101-e29691-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/122cded3104f/medi-101-e29691-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/14fe0b8f46ff/medi-101-e29691-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48f8/9333524/ebeafd5a8604/medi-101-e29691-g009.jpg

相似文献

1
Cardioprotective effect of Chinese herbal medicine for anthracycline-induced cardiotoxicity in cancer patients: A meta-analysis of prospective studies.中药防治蒽环类药物所致肿瘤患者心脏毒性的作用：前瞻性研究的荟萃分析。
Medicine (Baltimore). 2022 Jul 29;101(30):e29691. doi: 10.1097/MD.0000000000029691.
2
Medical interventions for treating anthracycline-induced symptomatic and asymptomatic cardiotoxicity during and after treatment for childhood cancer.儿童癌症治疗期间及治疗后用于治疗蒽环类药物引起的有症状和无症状心脏毒性的医学干预措施。
Cochrane Database Syst Rev. 2011 Sep 7(9):CD008011. doi: 10.1002/14651858.CD008011.pub2.
3
Statins as preventive therapy for anthracycline cardiotoxicity: a meta-analysis of randomized controlled trials.他汀类药物作为蒽环类药物心脏毒性的预防治疗：一项随机对照试验的荟萃分析。
Int J Cardiol. 2023 Nov 15;391:131219. doi: 10.1016/j.ijcard.2023.131219. Epub 2023 Jul 30.
4
Different dosage schedules for reducing cardiotoxicity in cancer patients receiving anthracycline chemotherapy.在接受蒽环类化疗的癌症患者中降低心脏毒性的不同给药方案。
Cochrane Database Syst Rev. 2006 Oct 18(4):CD005008. doi: 10.1002/14651858.CD005008.pub2.
5
Cardioprotective interventions for cancer patients receiving anthracyclines.针对接受蒽环类药物治疗的癌症患者的心脏保护干预措施。
Cochrane Database Syst Rev. 2005 Jan 25(1):CD003917. doi: 10.1002/14651858.CD003917.pub2.
6
Different dosage schedules for reducing cardiotoxicity in cancer patients receiving anthracycline chemotherapy.在接受蒽环类化疗的癌症患者中降低心脏毒性的不同给药方案。
Cochrane Database Syst Rev. 2009 Oct 7(4):CD005008. doi: 10.1002/14651858.CD005008.pub3.
7
Systematic Assessment of Chinese Medicine Compounds for Mitigating Anthracycline-Induced Cardiotoxicity.系统评价中药化合物减轻蒽环类药物所致心脏毒性的作用。
Altern Ther Health Med. 2024 Nov;30(11):404-409.
8
Effects of Traditional Chinese Medicine Injections for Anthracyclines-induced Cardiotoxicity: An Overview of Systematic Reviews and Meta-Analyses.中药注射剂治疗蒽环类药物相关性心脏毒性的系统评价和Meta 分析的综合评价。
Integr Cancer Ther. 2023 Jan-Dec;22:15347354231164753. doi: 10.1177/15347354231164753.
9
Different anthracycline derivates for reducing cardiotoxicity in cancer patients.用于降低癌症患者心脏毒性的不同蒽环类衍生物。
Cochrane Database Syst Rev. 2010 Mar 17(3):CD005006. doi: 10.1002/14651858.CD005006.pub3.
10
Different anthracycline derivates for reducing cardiotoxicity in cancer patients.用于降低癌症患者心脏毒性的不同蒽环类衍生物。
Cochrane Database Syst Rev. 2010 May 12;2010(5):CD005006. doi: 10.1002/14651858.CD005006.pub4.

引用本文的文献

1
Synergistic and Additive Effects of Herbal Medicines in Combination with Chemotherapeutics: A Scoping Review.草药与化疗药物联合使用的协同和相加作用：一项范围综述。
Integr Cancer Ther. 2024 Jan-Dec;23:15347354241259416. doi: 10.1177/15347354241259416.
2
Cardio-oncology: Examination of progress in China from an oncologist's perspective.心脏肿瘤学：从肿瘤学家视角审视中国的进展
Asia Pac J Oncol Nurs. 2024 Apr 17;11(6):100491. doi: 10.1016/j.apjon.2024.100491. eCollection 2024 Jun.
3
The Role of Epithelial Mesenchymal Transition (EMT) in Pathogenesis of Cardiotoxicity: Diagnostic & Prognostic Approach.
上皮间质转化（EMT）在心脏毒性发病机制中的作用：诊断和预后方法。
Mol Biotechnol. 2023 Sep;65(9):1403-1413. doi: 10.1007/s12033-023-00697-z. Epub 2023 Feb 27.
4
Advancing Cardio-Oncology in Asia.推动亚洲心血管肿瘤学发展。
Korean Circ J. 2023 Feb;53(2):69-91. doi: 10.4070/kcj.2022.0255.