Department of Health and Physical Education, Cooperative Faculty of Education, Gunma University, 4-2 Aramaki-machi, Maebashi, Gunma 371-8510, Japan.
Faculty of Medicine, Toho University Graduate School of Medicine, 5-21-16 Omorinishi, Ota-ku, Tokyo, Japan.
Physiol Behav. 2022 Oct 15;255:113930. doi: 10.1016/j.physbeh.2022.113930. Epub 2022 Jul 26.
Empathy, consisting of cognitive empathy and affective empathy, is essential for creating relationships with others. Since the genetic polymorphism of oxytocin receptor (OXTR) and arginine-vasopressin V1B receptor (AVPR1B) relate to prosocial behavior and empathy, it would need to innovate strategies for treating human empathy by considering individual genetic variations. Physical activity is expected as a possible strategy; here, we investigated the influences of genetic polymorphisms in OXTR SNP rs53576 and AVPR1B SNP rs28373064, on the relationships of self-reported empathy with physical activity.
The saliva is collected from a hundred Japanese college students for determining the individual polymorphism of OXTR SNP rs53576 (AA, AG, or GG genotype) and AVPR1B SNP rs28373064 (TT, TC, or CC genotype). In addition, the participants' self-reported cognitive and affective empathy, amounts of physical activity, and sitting time were evaluated with questionaries.
The participants with OXTR SNP rs53576 GG genotype showed a significant negative correlation between sitting time and cognitive empathy adjusted by age, gender, and sports experience. Further, there was a trend to correlate between physical activity amounts and cognitive empathy in the participants carrying the G variant in OXTR SNP rs53576 (AG or GG). As for AVPR1B SNP rs28373064, the persons with TT genotype exhibited a negative correlation trend between sitting time and cognitive empathy.
There are possible correlations between the self-reported cognitive empathy and physical activity amounts in the persons carrying the G variant of OXTR rs53576 or with the TT genotype for AVPR1B SNP rs28373064.
同理心包括认知同理心和情感同理心，对于与他人建立关系至关重要。由于催产素受体（OXTR）和精氨酸加压素 V1B 受体（AVPR1B）的基因多态性与亲社会行为和同理心有关，因此需要考虑个体遗传变异来创新治疗人类同理心的策略。体育活动有望成为一种可能的策略；在这里，我们研究了 OXTR SNP rs53576 和 AVPR1B SNP rs28373064 的遗传多态性对自我报告同理心与体育活动关系的影响。
从一百名日本大学生的唾液中提取个体的 OXTR SNP rs53576（AA、AG 或 GG 基因型）和 AVPR1B SNP rs28373064（TT、TC 或 CC 基因型）的遗传多态性。此外，通过问卷评估了参与者的自我报告认知同理心和情感同理心、体育活动量和久坐时间。
携带 OXTR SNP rs53576 GG 基因型的参与者，在调整年龄、性别和运动经验后，与认知同理心呈显著负相关。此外，在携带 OXTR SNP rs53576 的 G 变体（AG 或 GG）的参与者中，存在认知同理心与体育活动量之间的相关趋势。对于 AVPR1B SNP rs28373064，TT 基因型的个体在久坐时间和认知同理心之间存在负相关趋势。
在携带 OXTR rs53576 的 G 变体或携带 AVPR1B SNP rs28373064 的 TT 基因型的个体中，自我报告的认知同理心与体育活动量之间可能存在相关性。
