Department of Anesthesiology, Hospital de São João, Porto, Portugal.
Faculty of Medicine, University of Porto, Alameda do Professor Hernâni Monteiro, 4200-319, Porto, Portugal.
Sci Rep. 2022 Jul 29;12(1):13053. doi: 10.1038/s41598-022-16699-x.
We hypothesized that thalamic volumes of patients with type 1 diabetes mellitus (DM) and nonpainful diabetic peripheral neuropathy (DPN) would be reduced relative to thalamic volumes of patients with type 1 DM and painful DPN. We calculated the standardized thalamic volumetric difference between these groups in a pilot sample to obtain a statistical power of 80% at a 5% significance level. Hence, we measured thalamic volumes from 15 patients with nonpainful DPN (10 women, mean age = 49 years, standard deviation [SD] = 11.5) and from 13 patients with painful DPN (8 women, mean age = 43 years, SD = 12.5) by using a manual segmentation approach. A volumetric difference of approximately 15% was found between the nonpainful (mean = 5072 mm, SD = 528.1) and painful (mean = 5976 mm, SD = 643.1) DPN groups (P < 0.001). Curiously, a volumetric difference between the left (mean = 5198 mm, SD = 495.0) and the right (mean = 4946 mm, SD = 590.6) thalamus was also found in patients with nonpainful DPN (P < 0.01), but not in patients with painful DPN (P = 0.97). Patients with nonpainful DPN have lower thalamic volumes than those with painful DPN, especially in the right thalamus.
我们假设 1 型糖尿病（DM）和无痛性糖尿病周围神经病变（DPN）患者的丘脑体积会比 1 型 DM 和有痛性 DPN 患者的丘脑体积小。我们在一个试点样本中计算了这些组之间的标准化丘脑体积差异，以在 5%的显著水平上获得 80%的统计功效。因此，我们通过手动分割方法测量了 15 名无痛性 DPN 患者（10 名女性，平均年龄 49 岁，标准差 [SD] = 11.5）和 13 名有痛性 DPN 患者（8 名女性，平均年龄 43 岁，SD = 12.5）的丘脑体积。无痛性（平均= 5072 毫米，SD = 528.1）和有痛性（平均= 5976 毫米，SD = 643.1）DPN 组之间发现了大约 15%的体积差异（P < 0.001）。奇怪的是，在无痛性 DPN 患者中还发现了左（平均= 5198 毫米，SD = 495.0）和右（平均= 4946 毫米，SD = 590.6）丘脑之间的体积差异（P < 0.01），但在有痛性 DPN 患者中没有（P = 0.97）。无痛性 DPN 患者的丘脑体积低于有痛性 DPN 患者，尤其是右丘脑。
