多胎妊娠的延期间隔分娩：新生儿死亡率、发病率和发育情况。
Delayed-interval delivery in multiple gestation pregnancies: neonatal mortality, morbidity, and development.
机构信息
Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NC, USA.
出版信息
J Perinatol. 2022 Dec;42(12):1607-1614. doi: 10.1038/s41372-022-01462-x. Epub 2022 Jul 29.
OBJECTIVE
Delayed-interval delivery (DID) is the delivery of the first fetus in a multiple gestation pregnancy without prompt delivery of the remaining fetus(es). We aimed to assess infant outcomes of DID.
STUDY DESIGN
We performed a retrospective cohort study of infants born 22-28 weeks' gestation or weighing 401-1500 g. DID was defined as a passage of >24 h between the birth of firstborn and retained infants. Rates of mortality, morbidity, and developmental outcomes were compared within DID multiples, to other multiples not born by DID, and all infants in the Generic Database and follow-up datasets (excluding DID-born).
RESULTS
DID-born multiples were younger and smaller than other multiples. Retained infants had no significantly different rates of mortality and morbidities compared to their firstborn counterparts, apart from less bronchopulmonary dysplasia.
CONCLUSIONS
DID showed no evidence of harm and a potential benefit of decreased bronchopulmonary dysplasia mediated by increased gestational age and birthweight.
目的
延迟间隔分娩（DID）是指在多胎妊娠中，不立即分娩其余胎儿，而先分娩第一胎。我们旨在评估 DID 分娩的婴儿结局。
研究设计
我们对 22-28 周龄或体重 401-1500g 的婴儿进行了回顾性队列研究。DID 的定义为第一胎和保留胎儿之间的分娩时间间隔>24 小时。在 DID 多胎组、非 DID 多胎组和通用数据库及随访数据集（不包括 DID 分娩的婴儿）中的 DID 分娩婴儿之间比较死亡率、发病率和发育结局。
结果
DID 分娩的多胎婴儿比其他多胎婴儿更年轻、更小。与第一胎相比，保留婴儿的死亡率和发病率没有显著差异，除了支气管肺发育不良的发生率较低。
结论
DID 并未显示出有害的证据，并且通过增加胎龄和出生体重，可能有助于减少支气管肺发育不良。
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