Institute of Digestive Health and Liver Diseases, Mercy Medical Center, Baltimore, MD, 21202, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21202, USA.
Hepatol Int. 2022 Oct;16(5):993-1000. doi: 10.1007/s12072-022-10378-9. Epub 2022 Jul 29.
Acute-on-chronic liver failure (ACLF) is a dynamic syndrome associated with a very high short-term mortality. Hence, the ongoing assessment of treatment response, an expedited liver transplant evaluation and listing, and the determination of futility of treatment are critical for optimal outcomes. In this review, we appraise our current understanding of the timing and futility of liver transplantation, and the short- and long-term outcomes including the quality of life after deceased or live donor liver transplantation in those with ACLF.
急性慢性肝衰竭（ACLF）是一种与极高短期死亡率相关的动态综合征。因此，对治疗反应的持续评估、加速肝移植评估和列名，以及治疗无效性的确定对于最佳结果至关重要。在这篇综述中，我们评估了我们目前对肝移植时机和无效性的理解，以及在 ACLF 患者中进行死后或活体供肝移植后的短期和长期结局，包括生活质量。
