Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for Ophthalmology, Nanchang, Jiangxi, China.
BMC Ophthalmol. 2022 Jul 29;22(1):326. doi: 10.1186/s12886-022-02540-6.
To evaluate the safety, function, and cosmetic outcome of eyelid reconstruction using a xenogeneic acellular dermal matrix as a tarsal plate replacement in the repair of 50 to 100% eyelid defects following excision of large malignant tumours.
A retrospective, non-comparative, interventional study of 21 eyes was performed over 26 months. Fourteen patients were female and seven were male. In all cases, a xenogeneic acellular dermal matrix was used for total or subtotal replacement of the tarsal plate. The central vertical height of the palpebral fissure was measured immediately after eyelid margin incision and at 1 and 6 months postoperatively.
In patients who underwent surgery, the mean palpebral fissure height (PFH) was not significantly different between immediately and 1 month after incision (8.10 ± 0.562 mm vs 8.17 ± 0.577 mm, respectively; P > 0.05). After 6 months, PFH was 8.26 ± 0.605 mm, which was significantly different from that immediately after incision (P < 0.05). After 6 months of follow-up, all patients had a good aesthetic appearance after eyelid reconstruction, with no obvious graft dissolution or rejection, normal eyelid activity, and normal opening, closing, and lifting function. None of the 21 patients experienced tumour recurrence during postoperative follow-up.
The xenogeneic acellular dermal matrix was a successful tarsal plate replacement. This material is readily available, and a second surgical site is avoided. The xenogeneic acellular dermal matrix is considered a promising alternative material for tarsal replacement in future generations.
评估异种去细胞真皮基质作为眼砣板替代物在切除大型恶性肿瘤后修复 50%至 100%眼睑缺损中的安全性、功能和美容效果。
对 26 个月内的 21 只眼进行回顾性、非对照、干预性研究。14 例为女性，7 例为男性。所有病例均采用异种去细胞真皮基质进行全层或次全层眼砣板替代。在眼睑缘切开后即刻以及术后 1 个月和 6 个月测量睑裂中央垂直高度。
在接受手术的患者中，切口即刻与 1 个月时的平均睑裂高度（PFH）无显著差异（分别为 8.10±0.562mm 和 8.17±0.577mm；P＞0.05）。6 个月后，PFH 为 8.26±0.605mm，与切口即刻时相比差异有统计学意义（P＜0.05）。术后 6 个月随访时，所有患者眼睑重建后外观良好，无明显移植物溶解或排斥，眼睑活动正常，睁眼、闭眼和上睑提升功能正常。21 例患者术后均未出现肿瘤复发。
异种去细胞真皮基质是一种成功的眼砣板替代物。该材料易于获得，避免了二次手术部位。异种去细胞真皮基质被认为是未来眼砣替代物的一种有前途的替代材料。
