Research Group Psychosomatic Rehabilitation, Department of Psychosomatic Medicine, Charité Universitätsmedizin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
Rehabilitation Clinic Seehof, Department of Psychosomatic Medicine, Federal German Pension Agency, Lichterfelder Allee 55, 14513, Teltow, Germany.
BMC Psychol. 2022 Jul 29;10(1):189. doi: 10.1186/s40359-022-00892-8.
In Patients suffering from post-COVID syndrome, in addition to physical limitations, cognitive limitations, fatigue, dyspnea as well as depression and anxiety disorders may also be present. Up to now (as of May 2022), approx. 514 million people worldwide have been infected with SARS-CoV-2, in Germany this affects approx. 25 million. In Germany, 2.5 million people could potentially be affected by post-COVID syndrome. Post-COVID is thus a highly relevant public health issue. So far, there is no specific causal therapy for the post-COVID syndrome, but with multimodal symptom-oriented rehabilitation, the course can be favourably influenced. However, there is no study yet that focuses on patients in different rehabilitation indications and compares the focal symptomatology and coping strategies as well as the patients' benefit per indication.
METHODS/DESIGN: As first objective, pulmonal, cardiac, neurological, cognitive or/and psychological functional impairments in rehabilitation patients after COVID-19 disease will be described. The second objective is the differentiated review of the specific rehabilitation measures, in the short term and in the longer term for the purpose of future prognoses and optimisation of therapeutic interventions. This prospective, non-randomised, controlled longitudinal study, plus multi-group comparisons will take place in seven rehabilitation clinics of different specialisations: cardiological rehab, pneumological rehab, neurological rehab, psychosomatic rehab. Within 12 months, 1000 cases across all participating centres will be included. Somatic and psychological testing will be conducted at three measurement points: Admission (t0), discharge (t1), 6-montas Catamnesis (t2). The patients receive the usual care according to the respective rehabilitation priorities, adapted to the special challenges of post-COVID symptoms. Patients of the post-COVID outpatient clinic without rehabilitation will be used as a control group.
This study will precisely assess the extent to which subclinical neurological or/and psychological impairments are present in post-COVID-19 rehabilitation and the results will help, developing, providing and evaluating appropriate treatment concepts. This may also have relevant implications for the improvement of physical ability and quality of life in post-COVID-19 patients and increase the probability of return to work. Trial registration Z-2022-1749-8, registered 03. February 2022, https://studienanmeldung.zks-regensburg.de.
在患有新冠后综合征的患者中，除了身体受限，还可能存在认知受限、疲劳、呼吸困难以及抑郁和焦虑障碍。截至目前（截至 2022 年 5 月），全球约有 5.14 亿人感染了 SARS-CoV-2，德国约有 2500 万人受到影响。德国可能有 250 万人受到新冠后综合征的影响。因此，新冠后综合征是一个高度相关的公共卫生问题。目前，针对新冠后综合征还没有特定的病因治疗，但采用多模式、以症状为导向的康复治疗，可以有利地影响病程。然而，目前还没有研究关注不同康复适应证的患者，并比较焦点症状和应对策略以及每个适应证的患者获益。
方法/设计：作为第一个目标，将描述新冠后疾病康复患者的肺、心脏、神经、认知或/和心理功能障碍。第二个目标是针对特定康复措施进行差异化回顾，短期和长期来看，旨在预测未来，并优化治疗干预。这是一项前瞻性、非随机、对照的纵向研究，加上多组比较，将在七个不同专业的康复诊所进行：心脏康复、呼吸康复、神经康复、身心康复。在 12 个月内，将在所有参与中心纳入 1000 例病例。在三个测量点进行躯体和心理测试：入院时（t0）、出院时（t1）、6 个月随访时（t2）。患者接受根据各自康复重点制定的常规护理，以适应新冠后症状的特殊挑战。没有接受康复的新冠后门诊患者将作为对照组。
这项研究将精确评估亚临床神经或/和心理损伤在新冠后康复中的存在程度，研究结果将有助于开发、提供和评估适当的治疗概念。这也可能对改善新冠后患者的身体能力和生活质量以及提高重返工作岗位的可能性产生相关影响。试验注册 Z-2022-1749-8，于 2022 年 2 月 3 日注册，https://studienanmeldung.zks-regensburg.de。
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