University of Leicester, Department of Cardiovascular Sciences, Leicester, UK.
Nephrol Dial Transplant. 2023 May 31;38(6):1375-1384. doi: 10.1093/ndt/gfac230.
RNA interference (RNAi) occurs in all organisms and modulates most, if not all, biological pathways. It is the process by which non-coding RNAs, including microRNAs (miRNAs), regulate gene transcription and post-transcriptional processing of messenger RNA (mRNA). A single miRNA can modulate several genes within a cell, and several miRNAs can regulate expression of the same gene, adding tiers of complexity to the regulation of gene expression. miRNAs and other RNAi approaches have been successfully used in vitro and in vivo to selectively manipulate gene transcription, making them pivotal agents for basic science research and candidates for targeted therapeutics. This review focuses on miRNAs and their potential as biomarkers and novel therapeutics for glomerular disease.
RNA 干扰 (RNAi) 存在于所有生物体中，并调节大多数（如果不是全部）生物途径。它是非编码 RNA（包括 microRNAs (miRNAs)）调节基因转录和信使 RNA (mRNA) 转录后加工的过程。单个 miRNA 可以调节细胞内的几个基因，而几个 miRNA 可以调节同一个基因的表达，从而为基因表达的调控增加了复杂性。miRNAs 和其他 RNAi 方法已成功用于体外和体内选择性地操纵基因转录，使它们成为基础科学研究的关键试剂和靶向治疗的候选药物。本文综述了 miRNAs 及其作为肾小球疾病生物标志物和新型治疗药物的潜力。
