Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, 84105, Beer-Sheva, Israel.
Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, TX, USA.
Clin Exp Metastasis. 2022 Oct;39(5):727-742. doi: 10.1007/s10585-022-10176-5. Epub 2022 Jul 30.
Despite the significant progress made over the past decade with combination of molecular profiling data and the development of new clinical strategies, our understanding of metastasis remains elusive. Bone metastasis is a complex process and a major cause of mortality in breast and prostate cancer patients, for which there is no effective treatment to-date. The current review summarizes the routes taken by the metastatic cells and the interactions between them and the bone microenvironment. We emphasize the role of the specified niches and cues that promote cellular adhesion, colonization, prolonged dormancy, and reactivation. Understanding these mechanisms will provide better insights for future studies and treatment strategies for bone metastatic conditions.
尽管过去十年在结合分子谱数据和开发新的临床策略方面取得了重大进展，但我们对转移的理解仍然难以捉摸。骨转移是一个复杂的过程，也是乳腺癌和前列腺癌患者死亡的主要原因，目前尚无有效的治疗方法。本综述总结了转移细胞所采取的途径以及它们与骨微环境之间的相互作用。我们强调了特定小生境和提示的作用，这些小生境和提示促进了细胞黏附、定植、长期休眠和再激活。了解这些机制将为未来研究和治疗骨转移疾病提供更好的思路。
