细胞外基质调节转移之旅。
The Extracellular Matrix Modulates the Metastatic Journey.
机构信息
Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA; University of California Berkeley/University of California San Francisco Graduate Program in Bioengineering, San Francisco, CA, USA.
出版信息
Dev Cell. 2019 May 6;49(3):332-346. doi: 10.1016/j.devcel.2019.03.026.
Abstract
The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth, survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to drive metastasis and impair treatment. Here, we discuss how the tumor matrix regulates metastasis by fostering tumor cell invasion into the stroma and migration toward the vasculature. We describe the role of the tumor matrix in cancer cell intravasation and vascular dissemination. We examine the impact of the matrix on disseminated tumor cell extravasation and on tumor dormancy and metastatic outgrowth. Finally, we discuss the clinical outcome of therapeutics that normalize tumor-matrix interactions.
摘要
细胞外基质在肿瘤中受到干扰。肿瘤基质促进癌症的生长、存活和侵袭，并改变成纤维细胞和免疫细胞的行为，以促进转移并削弱治疗效果。在这里，我们讨论了肿瘤基质如何通过促进肿瘤细胞浸润基质和向血管迁移来调节转移。我们描述了肿瘤基质在癌细胞浸润和血管扩散中的作用。我们研究了基质对播散性肿瘤细胞渗出以及肿瘤休眠和转移生长的影响。最后，我们讨论了使肿瘤基质相互作用正常化的治疗方法的临床结果。
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