沙特朱拜勒地区献血者中的乙型肝炎、丙型肝炎和 HIV 模式。
Patterns of Hepatitis B, Hepatitis C and HIV Among Blood Donors in Samtah-Jazan Region.
机构信息
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, P.O. Box 1906, Gizan, 45142, Saudi Arabia.
Samtah General Hospital, Jazan Health, Gizan, Saudi Arabia.
出版信息
J Epidemiol Glob Health. 2022 Sep;12(3):304-310. doi: 10.1007/s44197-022-00051-7. Epub 2022 Jul 30.
BACKGROUND AND OBJECTIVE
Transfusion-transmitted infectious agents are amongst the major health burden worldwide. The purpose of this study was to evaluate the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) among blood donors in Samtah General Hospital, Jazan region, Saudi Arabia.
MATERIAL AND METHODS
In this retrospective study, blood donation records of all blood donors recruited between January 2019 and August 2020 were included for data acquisition. A total of 4977 blood donors' records were reviewed and data were analysed.
RESULTS
Hepatitis B profile showed 0.60% blood donors positive for hepatis B surface antigen (HBsAg). Nucleic acid testing (NAT) showed the presence of HBV-DNA in 0.4% of the blood donors. Anti-HBs and anti-HBc antibodies were reactive in 3.34% and 7.31% blood donors' units, respectively. Anti-HCV antibodies were reactive among 54 (1.09%) blood donors. Upon reviewing the NAT analysis results, 0.16% (08) blood donors showed the presence of HCV-RNA in their blood units. Anti-HIV antibodies were reactive in 8 (0.16%) blood donors.
CONCLUSION
It is concluded that the frequency of HBsAg is comparatively lower while anti-HCV positivity is higher in Samtah, Jazan as a region compared to other regions of the country. Further studies are warranted to evaluate the cause of HCV infection in this area. Frequency of HIV is uncommon in this area.
背景和目的
输血传播的传染病是全球主要的健康负担之一。本研究旨在评估沙特阿拉伯吉赞地区桑塔赫综合医院献血者中乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和人类免疫缺陷病毒（HIV）的流行情况。
材料和方法
在这项回顾性研究中，纳入了 2019 年 1 月至 2020 年 8 月期间招募的所有献血者的献血记录进行数据采集。共回顾了 4977 名献血者的记录并进行了数据分析。
结果
乙型肝炎病毒检测结果显示，0.60%的献血者乙型肝炎表面抗原（HBsAg）阳性。核酸检测（NAT）显示，0.4%的献血者存在乙型肝炎病毒 DNA。3.34%和 7.31%的献血者单位的抗乙型肝炎表面抗体和抗乙型肝炎核心抗体呈反应性。54 名（1.09%）献血者抗丙型肝炎病毒抗体呈反应性。在审查 NAT 分析结果时，0.16%（08）的献血者血液单位中存在丙型肝炎病毒 RNA。8 名（0.16%）献血者抗人类免疫缺陷病毒抗体呈反应性。
结论
与沙特其他地区相比，吉赞地区的 HBsAg 频率相对较低，而抗 HCV 阳性率较高。需要进一步研究评估该地区 HCV 感染的原因。该地区 HIV 频率较低。
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