POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.
Wiad Lek. 2022;75(6):1492-1499. doi: 10.36740/WLek202206112.
The aim: To study the features of morphoethiopathogenesis of acute appendicitis and the consequences after appendectomy.
Materials and methods: 10 preparations of human appendix were studied, from which 5 appendixes were normal in people who died in adulthood and old age and 5 processes were taken intraoperatively during appendectomy. Morphometric characteristics of the tissue structures of the preparations were compared with the systematic review data, the literature search by the following keywords: morphoethiopathy", "vermiform process", "lymphoepithelial formations", "digestive system", "lymphoid nodule", "Peyer's patches", "mucous membrane".
Results: Pathogenesis of acute appendicitis - it is a consistent, staged process that is completely subject to the laws of exudative inflammation in response to microbial aggression. Removal of the appendicular process should be approached carefully and based on possible immunological consequences. Removal of the appendix as an immunocompetent organ Unreasonable removal of pathohistological unchanged appendix has medical consequences (can lead to consequences such as colon cancer) and not only.
Conclusions: Our results suggest that the vermiform appendix retains its active function throughout human life. The study provides an overview with current knowledge about the etiology, pathogenesis and possible consequences of appendectomy as the main method of treatment of acute appendicitis. The search for ways to prevent appendicitis can be successful only by finding out the causes and factors that in some individuals cause the inability of the appendix to resist bacterial invasion. Appendix is necessary to fully support the immune responses of the digestive tract, but it belongs to the category of those organs, the loss of which during forced surgery does not cause significant damage to the body.
研究急性阑尾炎的形态发生病理及其阑尾切除术后的后果。
研究了 10 个人类阑尾标本，其中 5 个阑尾来自成年人和老年人死亡时的正常阑尾，5 个阑尾是在阑尾切除术中获得的。将标本的组织结构形态学特征与系统评价数据进行比较，并通过以下关键词进行文献检索：“形态发生病理学”、“阑尾”、“淋巴上皮形成”、“消化系统”、“淋巴结节”、“派尔氏斑”、“黏膜”。
急性阑尾炎的发病机制 - 它是一个一致的、阶段性的过程，完全受渗出性炎症对微生物侵袭的反应规律所支配。阑尾切除术的切除应该谨慎进行，并基于可能的免疫后果。阑尾作为一个免疫器官的切除 不合理地切除组织病理学不变的阑尾会带来医学后果（可能导致结肠癌等后果），而不仅仅是这样。
我们的研究结果表明，阑尾在人类的整个生命周期中都保持着其活跃的功能。该研究提供了一个概述，涵盖了急性阑尾炎的病因、发病机制和阑尾切除术作为主要治疗方法的可能后果的最新知识。只有了解导致某些个体的阑尾无法抵抗细菌入侵的原因和因素，才能成功地寻找预防阑尾炎的方法。阑尾对于充分支持消化道的免疫反应是必要的，但它属于那些器官的范畴，在强制手术中失去这些器官不会对身体造成重大损害。
