Health Sciences Center - CCS, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Center of Sports - CDS, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Nutr Res. 2022 Sep;105:97-104. doi: 10.1016/j.nutres.2022.06.006. Epub 2022 Jun 30.
Adults with obesity are at higher risk for developing hypovitaminosis D. Some studies suggest that reduced levels of serum 25-hydroxyvitamin D (25(OH)D) may also be related to disorders in cardiometabolic parameters. However, because of the association between 25(OH)D and obesity, we hypothesized that body composition can be a confounding factor in the association of 25(OH)D with cardiometabolic parameters, and that 25(OH)D is inversely associated with body composition and cardiometabolic parameters and directly associated with fat intake. The aim of this study was to analyze the associations between 25(OH)D with body composition, fat intake, and cardiometabolic parameters in adults with obesity. This cross-sectional study consisted of 52 adults with obesity (61.53% female; 37.50 ± 6.88 years; body mass index [BMI]: 33.60 ± 2.89 kg/m). Cardiometabolic parameters (fasting blood glucose, insulin resistance index, C-reactive protein, blood pressure, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and cholesterol), body mass, BMI, waist circumference, body fat percentage, and fat intake were evaluated. Body mass was negatively associated with 25(OH)D (β = -0.108; P = .048; and R² = 0.090) and BMI (β = -0.621; P = .031; and R² = 0.103), both adjusted for fat intake. 25(OH)D was positively associated with fat intake (β = 0.129; P = .045 and R² = 0.078) adjusted for sex, age, and skin color. Cardiometabolic parameters were not associated with 25(OH)D, even after adjusted by body composition variables. However, the high prevalence of hypovitaminosis D (75%) and the negative association between 25(OH)D and body composition reinforce the importance of analyzing and monitoring vitamin D status in this population.
肥胖成年人发生维生素 D 缺乏症的风险更高。一些研究表明，血清 25-羟维生素 D（25(OH)D）水平降低也可能与心脏代谢参数紊乱有关。然而，由于 25(OH)D 与肥胖之间存在关联，我们假设身体成分可能是 25(OH)D 与心脏代谢参数之间关联的混杂因素，并且 25(OH)D 与身体成分和心脏代谢参数呈负相关，与脂肪摄入量呈正相关。本研究旨在分析肥胖成年人中 25(OH)D 与身体成分、脂肪摄入量和心脏代谢参数之间的关系。这是一项横断面研究，共纳入 52 名肥胖成年人（女性占 61.53%；37.50±6.88 岁；体重指数[BMI]：33.60±2.89kg/m²）。评估了心脏代谢参数（空腹血糖、胰岛素抵抗指数、C 反应蛋白、血压、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯和胆固醇）、体重、BMI、腰围、体脂百分比和脂肪摄入量。体重与 25(OH)D 呈负相关（β=-0.108；P=0.048；R²=0.090），与 BMI 呈负相关（β=-0.621；P=0.031；R²=0.103），两者均经脂肪摄入量调整。25(OH)D 与脂肪摄入量呈正相关（β=0.129；P=0.045；R²=0.078），经性别、年龄和肤色调整。即使经过身体成分变量调整，心脏代谢参数与 25(OH)D 也没有相关性。然而，维生素 D 缺乏症的高患病率（75%）以及 25(OH)D 与身体成分之间的负相关关系，都强调了在该人群中分析和监测维生素 D 状态的重要性。
