一种长链非编码RNA精细调节水杨酸生物合成以平衡植物免疫与生长。

A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth.

作者信息

Liu Ningkun, Xu Yanzhuo, Li Qi, Cao Yuxin, Yang Dechang, Liu Shasha, Wang Xiaokang, Mi Yingjie, Liu Yang, Ding Chenxi, Liu Yan, Li Yong, Yuan Yao-Wu, Gao Ge, Chen Jinfeng, Qian Weiqiang, Zhang Xiaoming

机构信息

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

出版信息

Cell Host Microbe. 2022 Aug 10;30(8):1124-1138.e8. doi: 10.1016/j.chom.2022.07.001. Epub 2022 Jul 30.

DOI:10.1016/j.chom.2022.07.001

PMID:35908550

Abstract

Constitutive activation of plant immunity is detrimental to plant growth and development. Here, we uncover the role of a long non-coding RNA (lncRNA) in fine-tuning the balance of plant immunity and growth. We find that a lncRNA termed salicylic acid biogenesis controller 1 (SABC1) suppresses immunity and promotes growth in healthy plants. SABC1 recruits the polycomb repressive complex 2 to its neighboring gene NAC3, which encodes a NAC transcription factor, to decrease NAC3 transcription via H3K27me3. NAC3 activates the transcription of isochorismate synthase 1 (ICS1), a key enzyme catalyzing salicylic acid (SA) biosynthesis. SABC1 thus represses SA production and plant immunity via decreasing NAC3 and ICS1 transcriptions. Upon pathogen infection, SABC1 is downregulated to derepress plant resistance to bacteria and viruses. Together, our findings reveal lncRNA SABC1 as a molecular switch in balancing plant defense and growth by modulating SA biosynthesis.

摘要

植物免疫的组成型激活对植物生长发育有害。在此，我们揭示了一种长链非编码RNA（lncRNA）在微调植物免疫与生长平衡中的作用。我们发现一种名为水杨酸生物合成调控因子1（SABC1）的lncRNA在健康植物中抑制免疫并促进生长。SABC1招募多梳抑制复合体2至其邻近基因NAC3（该基因编码一个NAC转录因子），通过H3K27me3降低NAC3的转录。NAC3激活异分支酸合成酶1（ICS1）的转录，ICS1是催化水杨酸（SA）生物合成的关键酶。因此，SABC1通过降低NAC3和ICS1的转录来抑制SA产生和植物免疫。在病原体感染时，SABC1表达下调，从而解除对植物抗细菌和抗病毒能力的抑制。总之，我们的研究结果揭示lncRNA SABC1是通过调节SA生物合成来平衡植物防御与生长的分子开关。