Laboratory of Environmental Pollution Control, Department of Chemistry, Aristotle University of Thessaloniki, GR-541 24 Thessaloniki, Greece; Centre for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, Thessaloniki, 10th km Thessaloniki-Thermi Rd, GR 57001, Greece.
Centre for Research and Technology Hellas (CERTH)/Hellenic Institute of Transport (HIT), 6th km, Charilaou - Thermi Road, GR 57001, Thermi, Thessaloniki, Greece.
Sci Total Environ. 2022 Nov 20;848:157696. doi: 10.1016/j.scitotenv.2022.157696. Epub 2022 Jul 29.
Time spent within vehicles' cabin has been largely increased during the last years. As a result, the assessment of indoor dust quality is meaningful since dust can be a source of numerous emerging contaminants associated with adverse effects in human health. To this end, fourteen cars and ten trucks from the city of Thessaloniki, Northern Greece were selected to assess the quality of vehicles' microenvironments. An HRMS-based strategy was deployed for the target and non-target analysis of the collected samples. The target approach aimed at the accurate mass screening of nine organophosphate flame retardants (OPFRs) and nine per-/polyfluorinated compounds (PFAS), revealing mean concentrations for the OPFRs varied from <MQL-3409 ng/g for tris(1,3-dichloro-2-propyl) phosphate (TDCP), while the PFASs were either not detected (<MDL) or detected below the quantification limit (<MQL). To exploit the advanced technology of HRMS, a non-target analysis (NTA) workflow was also designed and employed, allowing the identification of 17 non-targets (plasticizers, PPCPs, pesticides and industrial chemicals) at identification confidence levels from 3 to 1. The statistical analysis between the positive findings and vehicles' conditions evidenced a possible of association just for individual cases. Lastly, a preliminary evaluation of human exposure to the target analytes was applied with the view to assess the potential harmful effects. All values were < 1 indicating no special effects because of exposure to this concentration level.
近年来，人们在车内的时间大大增加。因此，评估室内灰尘质量具有重要意义，因为灰尘可能是许多与人类健康不良影响相关的新兴污染物的来源。为此，选择了来自希腊北部塞萨洛尼基市的 14 辆汽车和 10 辆卡车来评估车辆微环境的质量。采用基于高分辨质谱（HRMS）的策略对采集的样本进行目标和非目标分析。目标方法旨在对九种有机磷阻燃剂（OPFRs）和九种全氟/多氟化合物（PFAS）进行精确质量筛查，结果表明 OPFRs 的浓度范围从 <MQL-3409ng/g 的三（1,3-二氯-2-丙基）磷酸（TDCP）到 3409ng/g，而 PFASs 则未检出（<MDL）或低于定量限（<MQL）。为了利用 HRMS 的先进技术，还设计并采用了非目标分析（NTA）工作流程，允许在从 3 到 1 的鉴定置信水平下识别 17 种非目标物（增塑剂、PPCPs、农药和工业化学品）。阳性发现与车辆状况之间的统计分析表明，仅在个别情况下可能存在关联。最后，应用了目标分析物的人体暴露初步评估，以评估潜在的有害影响。所有值均<1，表明由于暴露于该浓度水平，没有特殊影响。
